EIC Accelerator Challenge: Novel biomarker-based assays to guide personalised cancer treatment
HORIZON EIC Accelerator Blended Finance
Basic Information
- Identifier
- HORIZON-EIC-2023-ACCELERATORCHALLENGES-01
- Programme
- EIC Accelerator 2023
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- December 7, 2022
- Deadline
- January 10, 2023
- Deadline Model
- multiple cut-off
- Budget
- €1,135,239,839
- Min Grant Amount
- €500,000
- Max Grant Amount
- €17,500,000
- Expected Number of Grants
- 20
- Keywords
- HORIZON-EIC-2023-ACCELERATORCHALLENGES-01HORIZON-EIC-2023-ACCELERATOR-01
Description
This EIC Accelerator Challenge aims to improve the efficacy, safety and uptake of therapeutic approaches against refractory cancers, using novel comprehensive predictive, prognostic and companion diagnostic tests, in the context of precision oncology.
The overall goal of this Challenge is to support and accelerate the preclinical validation and/or clinical phase 1 work carried out by innovative SMEs (including start-ups, spinouts) and small midcaps to develop novel predictive, prognostic and companion diagnostic assays to guide cancer treatment. This Challenge has the following specific objectives:
- to develop novel companion diagnostic assays, including through liquid profiling to identify who, among cancer patients, is more likely to benefit from a given treatment (guided treatment);
- to develop novel predictive biomarker-based assays to identify who, among patients with potentially precancerous lesions, is more likely to develop cancer;
- to develop novel prognostic assays including through liquid profiling to identify who, among the cancer patients who underwent treatment, is more likely to recur;
- to develop novel companion diagnostic assays, including through liquid profiling to identify who, among the cancer patients receiving treatment, is more likely to develop side effects as a result of the treatment and,
- to develop novel monitoring biomarker-based assays to effectively monitor the clinical course of the disease.
As expected outcomes from this Challenge, clinicians will be able to:
- Identify, who among cancer patients, is more likely to benefit from a given treatment (guided treatment),
- Identify, who among patients with potentially precancerous lesions, is more likely to develop cancer,
- Identify, who among the cancer patients having underwent treatment, is more likely to recur,
- Identify who among the cancer patients receiving treatment, is more likely to develop side effects as a result of the treatment, affecting their quality of life and
- More effectively monitor the clinical course of the disease.
For further information, please see the EIC Work Programme 2023.
Eligibility & Conditions
General conditions
1. Admissibility conditions: To be an eligible applicant to EIC Accelerator, you must apply as one of the following eligible entities:
- a single company classified as a SME and established within a Member State or an Associated Country (see Annex 2 of the EIC Work Programme 2023); or
- a single company classified as a small mid-cap (up to 499 employees) established in a Member State or an Associated Country, but only for exceptional cases for rapid scale up purposes ; or
- One or more natural persons (including individual entrepreneurs) or legal entities, which are either:
a. From a Member State or an Associated Country intending to establish an SME or small mid-cap (as defined above) in a Member State or Associated Country by the time of signing the EIC Accelerator contract or, in case the equity only is awarded, at the latest when agreeing on its investment component;
b. Intending to invest in an SME or small mid-cap in a Member State or an Associated Country and who may submit a proposal on behalf of that SME or small mid-cap, provided that a prior agreement exist with the company. The contract will be signed with the beneficiary company only; or
c. From a non-associated third country intending to establish an SME (including start-ups) or to relocate an existing SME to a Member State or an Associated Country. Your company must prove its effective establishment in a Member State or an Associated Country at the time of submission of the full proposal.
The standard admissibility and eligibility conditions are detailed in Annex 2 of the EIC Work Programme 2023.
There are limitations on the number of times you can submit a proposal described in section in section IV (Table 8) of the EIC Work Programme 2023 on resubmission limits.
If you are currently a participant in an eligible project funded by Horizon Europe or Horizon 2020 then you may be able to apply through your existing project under the Fast Track scheme (see Annex 3 of the EIC Work Programme 2023). This scheme is managed by the funding body responsible for the existing project and applies to funding bodies listed in Annex 3. Applicants may also be able to apply if they have a project financed by an eligible programme managed by a Member State or an Associated Country under the pilot Plug-in scheme. The Plug-in scheme to apply to the EIC Accelerator is detailed in Annex 4 of the EIC Work Programme 2023.
Proposal page limits and layout: You must prepare your application (Short and Full application) on the EIC artificial intelligence-based IT platform via on-line forms, by answering a series of questions:
Short applications:
- An on-line form where you must summarise your proposal and respond to a set of questions on your innovation, your potential market and your team;
- A pitch-deck of up to ten (10) slides in pdf format;
- A video pitch of up to three (3) minutes where the core members of your team (up to three people) should provide the motivation for your proposal
Full applications:
- An on-line form that follows a methodology embedded in the EIC artificial intelligence-based IT platform that generates a full and detailed business plan with information on you company’s finances and structure;
- A pitch-deck to be used if invited to the interviews
2. Eligible countries: described in Annex 2 (General conditions for proposals) of the EIC Work Programme 2023.
Applicants from the United Kingdom can apply to the EIC Accelerator, but can only request and receive funding in the form of “grant only”. The signature of any grant agreement will be subject to the positive conclusion of the association negotiation with the United Kingdom.
3. Financial and operational capacity and exclusion: described in Annex 2 (General conditions for proposals) of the EIC Work Programme 2023.
- Award criteria, scoring and thresholds: described in section IV of the EIC Work Programme 2023
- Submission and evaluation processes: described in section IV of the EIC Work Programme 2023
- Indicative timeline for evaluation and grant agreement: described in section IV of the EIC Work Programme 2023
Call documents:
Frequently Asked Questions (FAQs)
MGA used for EIC actions under Horizon Europe (HE General MGA)
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
Funding & Tenders Portal FAQ – find the answers to most frequently asked questions on submission of proposals, evaluation and grant management.
Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.
National Contact Points (NCPs) – get guidance, practical information and assistance on participation in Horizon Europe. There are also NCPs in many non-EU and non-associated countries (‘third-countries’).
Enterprise Europe Network – contact your EEN national contact for advice to businesses with special focus on SMEs. The support includes guidance on the EU research funding.
IT Helpdesk – contact the Funding & Tenders Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.
European IPR Helpdesk assists you on intellectual property issues.
CEN-CENELEC Research Helpdesk and ETSI Research Helpdesk – the European Standards Organisations advise you how to tackle standardisation in your project proposal.
The European Charter for Researchers and the Code of Conduct for their recruitment – consult the general principles and requirements specifying the roles, responsibilities and entitlements of researchers, employers and funders of researchers.
Partner Search Services help you find a partner organisation for your proposal.
Latest Updates
In light of the disruptions caused by the conflict in the Middle East, the European Commission has carefully assessed the challenges experienced by partner organisations in the region. We acknowledge that this situation makes it difficult to complete project proposals for Horizon Europe calls on time.
As a result, the deadline of the EIC Accelerator cut-off for full (Step 2) proposals has been extended from 19 October to 8 November 2023 at 17:00:00 (CET).
At the same time, the 12-month limit to submit a full application following the successful evaluation of a short (Step 1) proposal is extended. Successful Step 1 applicants who exceed(ed) the maximum 12 months for submitting a full (Step 2) proposal between 7 June 2023 cut-off date and 8 November 2023 cut-off date, are allowed to submit a full (Step 2) proposal to the 8 November cut-off date.
Please consult this link for further information on deadline extension:
https://research-and-innovation.ec.europa.eu/news/all-research-and-innovation-news/deadline-extension-horizon-europe-calls-following-hamas-terrorist-attacks-across-israel-2023-10-18_en
Updated link to EIC Investment Guidelines document - this is located in the Topic Conditions section.
The deadline for the last EIC Accelerator cut-off for full (Step 2) proposals this year has been changed from 4 October to 19 October 2023. This change of date is to allow applicants additional time to complete their full proposals taking into account the temporary moratorium on the short (Step 1) proposals from 2 June to 3 July 2023.
At the same time, the 12-month limit to submit a full application following the successful evaluation of a short (Step 1) proposal is extended so that successful Step 1 applicants who pass(ed) the maximum 12 months for submitting a full (Step 2) proposal between 7 June 2023 cut-off date and 19 October 2023 cut-off date, are allowed to submit a full (Step 2) proposal to the 19 October cut-off date.
The EIC Accelerator is migrating to the Electronic Submission System hosted on the Funding and tender oppportunities portal. To accommodate the change for applicants, the deadline for submissions for the 7 June 2023 cut-off has been delayed with two weeks until 21 June 2023 at 17.00. For more information, including on how to submit your EIC Accelerator application, please consult the Frequently Asked Questions page on the EIC Website.