Environmental biotechnology applications in service of remediation of polluted ecosystems
HORIZON Research and Innovation Actions
Basic Information
- Identifier
- HORIZON-CL6-2025-01-ZEROPOLLUTION-03
- Programme
- Cluster 6 Call 01 - single stage
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- May 6, 2025
- Deadline
- September 17, 2025
- Deadline Model
- single-stage
- Budget
- €2,000,000
- Min Grant Amount
- €2,000,000
- Max Grant Amount
- €2,000,000
- Expected Number of Grants
- 1
- Keywords
- HORIZON-CL6-2025-01-ZEROPOLLUTION-03HORIZON-CL6-2025-01
Description
In line with the zero pollution action plan, successful proposals will address the remediation of polluted ecosystems through bio-based and nature-based solutions and ecosystem-based adaptation to climate change, in accordance with the European Climate Law.
Project results are expected to contribute to all the following expected outcomes:
- engage public authorities, scientists and operators in the protection and restoration of ecosystems through bio-based and nature-based solutions;
- integrate in local, regional and national plans and strategies for ecosystems restoration, bio-based and nature-based solutions able to remediate degraded soil, sediment, surface water and groundwater affected by pollutants and threats such as salinization, and improve their resilience to climate change and/or their capacity to reduce greenhouse gases emissions/increase carbon removals;
- take advantage of innovative tools enabled by digital innovation, including AI, for the remediation of pollution in emergency conditions.
Degradation of soil, sediment and water due to anthropogenic causes may result from continuous exposure to pollution and/or unsustainable exploitation, but also from sudden accidents. Degradation may be exacerbated by negative effects of climate change or other threats (e.g., heat waves, fires, floods and landslides, soil/coastal erosion, ocean acidification, etc.). Moreover, in case both the exposure of soil, sediment and water to degrading factors and their vulnerability are high, whereas their resilience is low, the degradation may take the dimension of a disaster. The scope of this topic is the remediation of contaminated soil, sediment and water from pollutants, such as hazardous chemicals, pharmaceutical and waste, including litter and plastics, and their further restoration, including in case of accidents and disasters driven by anthropogenic activities and extreme climate and environmental events. The results from projects funded under this topic will contribute to one of the restoration measures included in the Nature Restoration Regulation to (Annex VII, point (32) Stop, reduce or remediate pollution from pharmaceuticals, hazardous chemicals, urban and industrial wastewater, and other waste including litter and plastics as well as light in all ecosystems). Project results will also help Member States to implement national adaptation strategies that promote nature-based solutions and ecosystem-based adaptation to climate change, in accordance with the European Climate Law.
Proposals should:
- select and analyse a set of case-studies of degraded soil, sediment and water affected by pollution and contaminants in the EU and Associated Countries. This could include cases where the degradation is exacerbated by climate change or biodiversity loss or other natural events or anthropogenic forcings;
- include a task in the project to develop bio-based solutions for the environmental remediation of the degraded soil, sediment and water in the selected case-studies, driven by biotechnology applications, and the integration of such bio-based solutions with nature-based solutions. The task should include the assessment of the alignment with the precautionary principle, environmental sustainability and efficiency of the developed solutions in remediating soil, sediment and water, also addressing biodiversity loss and the functional state of the ecosystems. Moreover, it should evaluate the improvement of resilience to the impacts of climate change on the affected ecosystems, due to the applications of the developed solutions;
- include a task in the project on the development of models enabled by digital innovation, including based on artificial intelligence, for the optimization of remediation approaches, also in case of emergency facing disaster sand extreme climate and environmental events like fires, droughts, floods, etc.;
- identify and assess the economic, social and safety risks and benefits of the remediation activities in the selected case-studies, in particular in terms of circular economy and of the reduction of the risks for human health resulting from exposure to the contaminants (e.g., vulnerable populations, integrating the gender dimension). The risk reduction should take into consideration the bioavailability and mobility of the contaminants, including heavy metals, other metals (e.g., the ones used in electronic devices, Li, REE, etc.), plastics and organic chemicals (i.e., PFAS, PAHs, pesticides, etc.);
- include a task in the project to deliver the overall environmental, economic, social and safety risk assessment for the developed integrated bio-based and nature-based solutions.
Proposals should include a task dedicated to sharing methodologies and findings with all projects funded under this topic and with similar recent or ongoing projects, e.g., those funded under the topic HORIZON-CL6-2021-ZEROPOLLUTION-01-10: Environmental services: improved bioremediation and revitalization strategies for soil, sediments and water, or under the topic HORIZON-CL6-2023-ZEROPOLLUTION-01-6: Biosensors and user-friendly diagnostic tools for environmental services.
Integrating Citizen Science in research approach is encouraged to contribute to the selection and analysis of case-studies of degraded ecosystems. This topic requires the effective contribution of SSH disciplines, including citizen social science approach and gender studies, especially for the risk assessment on human health. Multi-actor approach and international cooperation are encouraged.
The JRC may contribute with its expertise related to chemical pollutants in the environment and bio-based approaches, as well as to the interface between the research activities and regulatory aspects.
Destination & Scope
This destination serves the zero-pollution ambition for a toxic-free environment, as set out in the European Green Deal, towards the 2030 zero pollution targets for air, water and soils. The objectives of the EU’s chemicals strategy for sustainability, including the focus on PFAS (the ‘forever chemicals’). R&I under this destination will contribute to reach the 2030 targets for pollution reduction, by pursuing the precautionary principle and an effective ‘zero pollution hierarchy’1, prioritising preventive measures.
Proposed activities related to ocean and seas will be aimed at the implementation of the zero-pollution action plan within the scope of the Marine Strategy Framework Directive and the EU water legislation as well as the European Ocean Pact.
The destination will also support the implementation of the revised legislation on industrial emissions and air quality, by promoting innovative monitoring and modelling systems. It will support sustainable solutions to prevent and reduce pollution from agriculture ensuring long-term competitiveness and sustainability of the farming sector within planetary boundaries, and address pollution stemming from food and drink industries, in line with the objectives of the common agricultural policy, the announced future EU Vision for agriculture and food, and the Food 2030 initiative.
The development of innovative solutions and clean technologies in bio-based industrial sectors towards a zero-pollution and clean industrial approach is also in scope of this destination, in line with the industrial carbon management strategy and the European Climate Law, and the upcoming update of the bioeconomy strategy, underpinned by the principles of the circular economy and enabled by innovative approaches, to support the Commission communication “A Competitive Compass for the EU”, the announced strategy for European life sciences and the EU biotech act.
R&I initiatives within this destination will contribute to the objectives of the EU biodiversity strategy for 2030 and the Nature Restoration Regulation, by addressing pollution as one of the main drivers of biodiversity loss as well as for the protection of the EU natural capital.
Proposals for topics under this destination should set out a credible pathway to "achieve a clean environment, ensure water resilience, and enable the transformative change necessary to reduce air, water and soil pollution to levels no longer considered harmful to health and natural ecosystems, while respecting planetary boundaries". More specifically, they should contribute to one or several of the following impacts:
- enhanced scientific capacity and innovative solutions for detecting and characterising pollution sources, pathways, distribution, and cumulative impacts, including pollutants of great and emerging concern, assisted by AI domain and improved environmental observation and modelling systems, resulting in cleaner air and healthier ocean, seas, waters and soils;
- safe and sustainable by design bio-based (Commission Recommendation (EU) 2022/2510) solutions are developed for and by the bio-based industries, also through innovative biotechnology and biomanufacturing techniques, to contribute to climate neutrality and replace harmful chemicals in industrial bio-based processes and products;
- sustainable bio-based and nature-based solutions will be developed and tested to remediate polluted environments;
- food systems adopt the zero pollution ambition, preventing and reducing pollution in water, air, and soil;
- farmers are empowered to make informed management decisions on water, carbon, nutrients and greenhouse gas balances for environmental, social and economic sustainability, preventing and reducing pollution from agriculture.
The expected impacts from actions under Destination 4 will be maximised by the complementarities and synergies with other instruments within Horizon Europe and other programmes, like co-funded partnerships Water security for the planet (Water4All), Sustainable food systems for people, planet and climate, Sustainable Blue Economy, Agroecology and Biodiversa+; and the Horizon Europe Missions ‘A Soil Deal for Europe’, ‘Restore our Ocean and Waters by 2030’ and ‘Climate-Neutral Smart Cities’. Collaboration with the institutionalized partnership Circular Bio-based Europe Joint Undertaking will help industrial bio-based systems to replace harmful processes and substances, while fostering the use of sustainable natural resources.
Complementarities with Destinations 1 and 5 will enhance understanding of ecosystem adaptation and resource management under climate change, while addressing freshwater and groundwater challenges and strengthening water resilience.
To maximise the impacts of R&I under this Destination, international cooperation is encouraged.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
The Joint Research Centre (JRC) may participate as member of the consortium selected for funding.
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025). [[This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’ or through this link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/ls-decision_he_en.pdf]].
described in Annex G of the Work Programme General Annexes.
Specific conditions
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA, IA)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
Funding & Tenders Portal FAQ – find the answers to most frequently asked questions on submission of proposals, evaluation and grant management.
Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.
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IT Helpdesk – contact the Funding & Tenders Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.
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The European Charter for Researchers and the Code of Conduct for their recruitment – consult the general principles and requirements specifying the roles, responsibilities and entitlements of researchers, employers and funders of researchers.
Partner Search help you find a partner organisation for your proposal.
Latest Updates
PROPOSAL NUMBERS
Call HORIZON-CL6-2025-01 has closed on 17/09/2025
515 proposals have been submitted.
The breakdown per topic is:
·HORIZON-CL6-2025-01-BIODIV-01 : 1
·HORIZON-CL6-2025-01-BIODIV-02 : 15
·HORIZON-CL6-2025-01-BIODIV-03 : 11
·HORIZON-CL6-2025-01-BIODIV-04 : 22
·HORIZON-CL6-2025-01-BIODIV-05 : 24
·HORIZON-CL6-2025-01-BIODIV-06 : 19
·HORIZON-CL6-2025-01-BIODIV-07 : 17
·HORIZON-CL6-2025-01-BIODIV-08 : 11
·HORIZON-CL6-2025-01-BIODIV-09 : 23
·HORIZON-CL6-2025-01-BIODIV-10 : 26
·HORIZON-CL6-2025-01-CIRCBIO-01 : 35
·HORIZON-CL6-2025-01-CIRCBIO-02 : 11
·HORIZON-CL6-2025-01-CIRCBIO-03 : 13
·HORIZON-CL6-2025-01-CIRCBIO-04 : 9
·HORIZON-CL6-2025-01-CIRCBIO-05 : 17
·HORIZON-CL6-2025-01-CIRCBIO-06 : 21
·HORIZON-CL6-2025-01-CIRCBIO-07 : 22
·HORIZON-CL6-2025-01-CIRCBIO-08 : 25
·HORIZON-CL6-2025-01-CIRCBIO-09 : 15
·HORIZON-CL6-2025-01-CIRCBIO-10 : 3
·HORIZON-CL6-2025-01-CIRCBIO-11 : 5
·HORIZON-CL6-2025-01-CIRCBIO-12 : 2
·HORIZON-CL6-2025-01-CIRCBIO-13 : 21
·HORIZON-CL6-2025-01-CIRCBIO-14 : 12
·HORIZON-CL6-2025-01-CIRCBIO-15 : 2
·HORIZON-CL6-2025-01-ZEROPOLLUTION-01 : 16
·HORIZON-CL6-2025-01-ZEROPOLLUTION-02 : 3
·HORIZON-CL6-2025-01-ZEROPOLLUTION-03 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-04 : 9
·HORIZON-CL6-2025-01-ZEROPOLLUTION-05 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-06 : 19
·HORIZON-CL6-2025-01-ZEROPOLLUTION-07 : 16
Evaluation results are expected to be communicated in January 2026.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved. In addition to the information published in the topic page, you can always find a full description of the 7 destinations (Biodiversity and ecosystem services; Fair, healthy and environment-friendly food systems from primary production to consumption; Circular economy and bioeconomy sectors; Clean environment and zero pollution; Land, ocean and water for climate action; Resilient, inclusive, healthy and green rural, coastal and urban communities; Innovative governance, environmental observations and digital solutions in support of the Green Deal) that are relevant for the call in the Work Programme 2025 part for “Food, Bioeconomy, Natural Resources, Agriculture and Environment”. Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.