Substances of concern and emerging pollutants from bio-based industries and products: mapping and replacement
HORIZON Innovation Actions
Basic Information
- Identifier
- HORIZON-CL6-2025-01-ZEROPOLLUTION-01-two-stage
- Programme
- Cluster 6 Call 01 - two stage
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- May 6, 2025
- Deadline
- September 4, 2025
- Deadline Model
- two-stage
- Budget
- €10,000,000
- Min Grant Amount
- €5,000,000
- Max Grant Amount
- €5,000,000
- Expected Number of Grants
- 2
- Keywords
- HORIZON-CL6-2025-01-ZEROPOLLUTION-01-two-stageHORIZON-CL6-2025-01-two-stage
Description
In line with the chemical strategy for sustainability and the revision of the Industrial Emissions Directive, successful proposals will support the deployment of safe and sustainable by design bio-based industries and products, contributing to the de-fossilization and to the climate neutrality of EU industrial systems in a sustainable way.
Project results are expected to contribute to all of the following expected outcomes:
- stakeholders of bio-based value chains, including in public procurement, researcher centres, industries, public administrations, final consumers, etc., gain awareness on the releases of hazardous substances, emerging pollutants and substances which are persistent and liable to bio-accumulate in ecosystems from bio-based industrial processes and from bio-based products;
- bio-based industries operators and customers improve their knowledge and use of safe and sustainable bio-based alternatives replacing hazardous substances, to achieve healthier air, water and soil.
Preventing hazardous emissions at source is key to reach the 2030 pollution reduction targets, including substances of concern, very high concern and emerging pollutants (e.g., PFAS and endocrine disrupting chemicals) as defined in relevant pieces of legislation (e.g., REACH, ESPR, Batteries regulation). Bio-based innovative solutions, also in line with the recent initiative on biotechnology and biomanufacturing and the industrial carbon management strategy, should be designed to provide the solutions to replace hazardous substances in industrial assets and in final products and materials. Bio-based materials and products within the scope of this topic do not include food/feed, biofuels and bioenergy.
The proposals should:
- track presence of substances of very high concern and of concern, emerging pollutants and substances which are persistent and liable to bio-accumulate in ecosystems emitted from a selection of bio-based materials and products. This includes substances released in all the life phases of bio-based materials and products, during their use and their end-of-life. Evaluate the exposure of targeted end users to the substances, including integrating the gender dimension (sex and gender analysis) and vulnerable groups;
- include a task for the project to perform a full risk assessment of the substances emitted from the selected bio-based materials and products, also assessing the impacts on affected ecosystems and the risk for biodiversity loss;
- track presence of substances of very high concern and of concern, emerging pollutants and substances which are persistent and liable to bio-accumulate in ecosystems, emitted from a selection of industrial bio-based systems;
- include a task for the project to identify and improve a set of bio-based safe and sustainable by design (Commission Recommendation (EU) 2022/25) and circular solutions, to replace hazardous substances and to increase the resources efficiency, both at the level of industrial processes and in final materials and products selected under the first and the third bullet points of this scope. The number of bio-based solutions provided is not pre-defined. The task should include the assessment of the reduction of substances of concern and emerging pollutants, derived from the substitution;
- describe the collection of recommendations and best practices to replace substances of concern with safe and sustainable by design bio-based alternatives.
Proposals should include a task dedicated to sharing methodologies and findings with all projects funded within this topic. Moreover, the projects should collect and analyse the outcomes from past and ongoing projects under EU programmes, including the Circular Bio-based Europe Joint Undertaking, addressing the challenges in the scope of this topic.
For depollution to achieve zero pollution in large industrial installations, please refer to the Innovation Centre for Industrial Transformation and Emissions (INCITE) (https://innovation-centre-for-industrial-transformation.ec.europa.eu/).
Citizen Science is encouraged as a research approach for this topic. Citizen science activities should be conducted with the guidance and in close co-operation with researchers. This topic requires the effective contribution of SSH disciplines, including citizen social science and gender studies, especially in the task on risk assessment.
Multi-actor approach and international cooperation are encouraged.
Destination & Scope
This destination serves the zero-pollution ambition for a toxic-free environment, as set out in the European Green Deal, towards the 2030 zero pollution targets for air, water and soils. The objectives of the EU’s chemicals strategy for sustainability, including the focus on PFAS (the ‘forever chemicals’). R&I under this destination will contribute to reach the 2030 targets for pollution reduction, by pursuing the precautionary principle and an effective ‘zero pollution hierarchy’1, prioritising preventive measures.
Proposed activities related to ocean and seas will be aimed at the implementation of the zero-pollution action plan within the scope of the Marine Strategy Framework Directive and the EU water legislation as well as the European Ocean Pact.
The destination will also support the implementation of the revised legislation on industrial emissions and air quality, by promoting innovative monitoring and modelling systems. It will support sustainable solutions to prevent and reduce pollution from agriculture ensuring long-term competitiveness and sustainability of the farming sector within planetary boundaries, and address pollution stemming from food and drink industries, in line with the objectives of the common agricultural policy, the announced future EU Vision for agriculture and food, and the Food 2030 initiative.
The development of innovative solutions and clean technologies in bio-based industrial sectors towards a zero-pollution and clean industrial approach is also in scope of this destination, in line with the industrial carbon management strategy and the European Climate Law, and the upcoming update of the bioeconomy strategy, underpinned by the principles of the circular economy and enabled by innovative approaches, to support the Commission communication “A Competitive Compass for the EU”, the announced strategy for European life sciences and the EU biotech act.
R&I initiatives within this destination will contribute to the objectives of the EU biodiversity strategy for 2030 and the Nature Restoration Regulation, by addressing pollution as one of the main drivers of biodiversity loss as well as for the protection of the EU natural capital.
Proposals for topics under this destination should set out a credible pathway to "achieve a clean environment, ensure water resilience, and enable the transformative change necessary to reduce air, water and soil pollution to levels no longer considered harmful to health and natural ecosystems, while respecting planetary boundaries". More specifically, they should contribute to one or several of the following impacts:
- enhanced scientific capacity and innovative solutions for detecting and characterising pollution sources, pathways, distribution, and cumulative impacts, including pollutants of great and emerging concern, assisted by AI domain and improved environmental observation and modelling systems, resulting in cleaner air and healthier ocean, seas, waters and soils;
- safe and sustainable by design bio-based (Commission Recommendation (EU) 2022/2510) solutions are developed for and by the bio-based industries, also through innovative biotechnology and biomanufacturing techniques, to contribute to climate neutrality and replace harmful chemicals in industrial bio-based processes and products;
- sustainable bio-based and nature-based solutions will be developed and tested to remediate polluted environments;
- food systems adopt the zero pollution ambition, preventing and reducing pollution in water, air, and soil;
- farmers are empowered to make informed management decisions on water, carbon, nutrients and greenhouse gas balances for environmental, social and economic sustainability, preventing and reducing pollution from agriculture.
The expected impacts from actions under Destination 4 will be maximised by the complementarities and synergies with other instruments within Horizon Europe and other programmes, like co-funded partnerships Water security for the planet (Water4All), Sustainable food systems for people, planet and climate, Sustainable Blue Economy, Agroecology and Biodiversa+; and the Horizon Europe Missions ‘A Soil Deal for Europe’, ‘Restore our Ocean and Waters by 2030’ and ‘Climate-Neutral Smart Cities’. Collaboration with the institutionalized partnership Circular Bio-based Europe Joint Undertaking will help industrial bio-based systems to replace harmful processes and substances, while fostering the use of sustainable natural resources.
Complementarities with Destinations 1 and 5 will enhance understanding of ecosystem adaptation and resource management under climate change, while addressing freshwater and groundwater challenges and strengthening water resilience.
To maximise the impacts of R&I under this Destination, international cooperation is encouraged.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
Applicants submitting a proposal under the blind evaluation pilot (see General Annex F) must not disclose their organisation names, acronyms, logos nor names of personnel in the proposal abstract and Part B of their first-stage application (see General Annex E).
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
This topic is part of the blind evaluation pilot under which first stage proposals will be evaluated blindly.
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
described in Annex G of the Work Programme General Annexes.
Specific conditions
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA, IA)
Standard application form (HE RIA IA Stage 1)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
Standard evaluation form (HE RIA, IA and CSA Stage 1)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
Funding & Tenders Portal FAQ – find the answers to most frequently asked questions on submission of proposals, evaluation and grant management.
Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.
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IT Helpdesk – contact the Funding & Tenders Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.
European IPR Helpdesk assists you on intellectual property issues.
CEN-CENELEC Research Helpdesk and ETSI Research Helpdesk – the European Standards Organisations advise you how to tackle standardisation in your project proposal.
The European Charter for Researchers and the Code of Conduct for their recruitment – consult the general principles and requirements specifying the roles, responsibilities and entitlements of researchers, employers and funders of researchers.
Partner Search help you find a partner organisation for your proposal.
Latest Updates
PROPOSAL NUMBERS
Call HORIZON-CL6-2025-01-two-stage has closed on 04/09/2025.
125 proposals have been submitted.
The breakdown per topic is:
- HORIZON-CL6-2025-01-BIODIV-01-two-stage: 32
- HORIZON-CL6-2025-01-BIODIV-02-two-stage: 55
- HORIZON-CL6-2025-01-CIRCBIO-01-two-stage: 31
- HORIZON-CL6-2025-01-ZEROPOLLUTION-01-two-stage: 7
Evaluation results are expected to be communicated in December 2025.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved. In addition to the information published in the topic page, you can always find a full description of the 7 destinations (Biodiversity and ecosystem services; Fair, healthy and environment-friendly food systems from primary production to consumption; Circular economy and bioeconomy sectors; Clean environment and zero pollution; Land, ocean and water for climate action; Resilient, inclusive, healthy and green rural, coastal and urban communities; Innovative governance, environmental observations and digital solutions in support of the Green Deal) that are relevant for the call in the Work Programme 2025 part for “Food, Bioeconomy, Natural Resources, Agriculture and Environment”. Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.