Bioprospecting and optimised production of marine/aquatic natural products in the omics & artificial intelligence era
HORIZON Innovation Actions
Basic Information
- Identifier
- HORIZON-CL6-2025-01-CIRCBIO-14
- Programme
- Cluster 6 Call 01 - single stage
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- May 6, 2025
- Deadline
- September 17, 2025
- Deadline Model
- single-stage
- Budget
- €2,000,000
- Min Grant Amount
- €2,000,000
- Max Grant Amount
- €2,000,000
- Expected Number of Grants
- 1
- Keywords
- HORIZON-CL6-2025-01-CIRCBIO-14HORIZON-CL6-2025-01Biochemistry and molecular biologyCell biology, MicrobiologyChemical sciencesComputer sciences, information science and bioinformaticsEnzymesIndustrial biotechnologyMarine BiotechnologyMarine biology
Description
Successful proposals should contribute to reaching the impacts of this destination, and European policies, in particular the European Green Deal, the bioeconomy strategy, the new approach for a blue economy. They should help harnessing the full potential of marine and freshwater biological resources and blue biotechnology is leveraged to deliver societal benefits, such as greener more environmentally friendly industrial products and processes, support public health and environmental conservation.
Project results are expected to contribute to all of the following expected outcomes:
- demonstrating the broadened range of more sustainable and more accessible marine/aquatic natural products with high value applications;
- demonstrating advances in the development and/or application related computational tools such as AI etc. in the biodiscovery pipeline;
- increased commitment to biodiversity preservation and conservation through enabling bioproduction routes (biosynthesis, fermentation, culturing) of natural products, ensuring that the biodiscovery of new compounds does not lead to unsustainable harvesting from the wild and a sustainable use of genetic diversity;
- awareness raised and creation of a better framework for blue biotechnology innovation and uptake through broad stakeholder engagement, supporting the EU biotechnology and biomanufacturing initiative.
The immense diversity of marine/aquatic micro- and macro-organisms and their communities represents a rich and largely unexplored reservoir of natural products and their base ingredients. To survive in habitats ranging from deep-sea sediments to polar regions or shallow waters, marine organisms have developed a broad spectrum of structures, defense mechanisms and metabolic pathways resulting in natural products with vast chemical diversity and wide range of biological activities. The biological interplay between interspecies communities, e.g. symbiotic or defence mechanisms, may offer attractive leads and is also in scope. For the coverage of terrestrial bioprospecting see parallel topic HORIZON-CL6-2025-01-CIRCBIO-08: Bioprospecting and optimized production of the terrestrial natural products: new opportunities for bio-based sectors.
The action covers modern biodiscovery approaches including, in-silico bioprospecting and the full integration of digital methods (e.g., statistics, algorithms, AI, data science, modelling, digital twins) with bioinformatics and biotechnological tools, which make possible the identification and production of bioactive natural compounds with potential high-value application in sectors such as pharmaceuticals, nutraceuticals, cosmetics, food/feed additives, agrochemicals, etc. In the context of this topic, natural products are understood as biologically active products such as secondary metabolites as well as enzymes derived from marine/aquatic organisms.
Targeted marine/aquatic biological resources can be sourced from their natural environment (in-situ) and/or from open access and public/private collections and gene-banks (ex-situ).
The aim is to broaden the range of novel compounds, lowering the production costs, quicken the development pipeline, and enable more innovation for the industrial operators, with clear-cut benefits for the final users. Projects should have a strong industry drive and include demonstration activities to proof the techno/economic viability of the production of the proposed marine/aquatic natural product(s) and/or the biodiscovery platform tools combining digital and biotechnologies.
The scope covers relevant steps of the biodiscovery process such as isolation and characterization of microbial strains and consortia, genomic characterisation, creation of natural product libraries, bioactivity screening, natural products isolation and purification, chemical structure elucidation or optimized production pathways via biotechnology and biomanufacturing approaches in suitable industrial facilities (bioreactors/biorefineries, e.g. for microbial production), synthetic biology or gene editing. The integration of digital approaches (AI, computer algorithms such as machine learning, modelling, data science etc) on optimizing the biodiscovery processes such as identification of biosynthetic gene clusters and metabolic pathways, enzyme selection, combinatorial assembly and annotation of high-throughput DNA sequencing data, bioactivity prediction, elucidation of the structure of compounds, experimental design etc is in scope. Safety to the end-users and operators needs to be assessed and guaranteed.
Proposals should avoid overlaps with past or ongoing topics (e.g. projects funded under the topic HORIZON-CL6-2022-CIRCBIO-02-05-two-stage: Life sciences and their convergence with digital technologies for prospecting, understanding and sustainably using biological resources, topic HORIZON-CL6-2023-CIRCBIO-01: Broadening the spectrum of robust enzymes and microbial hosts in industrial biotechnology), consider synergies to parallel actions (e.g. HORIZON-CL6-2025-01-CIRCBIO-08: Bioprospecting and optimized production of the terrestrial natural products: new opportunities for bio-based sectors as well as funded under the topic HORIZON-2020-FNR-11-2020 - Prospecting aquatic and terrestrial natural biological resources for biologically active compounds [1]). The action is expected to establish links with relevant projects funded under the EU Mission Restore our Ocean and Waters.
The action needs to guarantee biodiversity preservation. This can be addressed, inter alia, by covering propagation of biological material, including by in vitro cultivation, as well as by biotechnology approaches. The action needs to comply with applicable EU regulations and international rules on access to biological resources, their sustainable use and the fair and equitable sharing of benefits from their utilisation, including the Nagoya protocol, the Kunming-Montreal Global Biodiversity Framework (KM-GBF), and the agreement on the conservation and sustainable use of marine biological diversity of areas beyond national jurisdiction (BBNJ). A life-cycle assessment should be carried out to evaluate the environmental, economic, and social impact of the developed product(s). Proposals should contribute to the understanding of potential trade-offs inherent in the exploitation of ecosystems, their potential to deliver ecosystem services and ideally provide solution approaches to address these trade-offs. Potential risks to the environment, ecosystems, and society as well as benefits should also be assessed under this topic.
Proposals are encouraged to consider, where relevant, the services offered by European research infrastructures such as EU-OPENSCREEN, ELIXIR, EMBRC ERIC, IBISBA or other relevant research infrastructures138.
[1] https://cordis.europa.eu/programme/id/H2020_FNR-11-2020/en
Destination & Scope
Under Destination “Circular economy and bioeconomy sectors’, R&I in 2025 provides scientific and technological support to the European Green Deal, in line with the new Commission priority on “A new plan for Europe’s sustainable prosperity and competitiveness”.
Actions focus on the implementation of a wide range of EU initiatives such as the circular economy action plan and the upcoming Circular Economy Act, the EU bioeconomy strategy and its upcoming update, the forest strategy for 2030, and the Common Agriculture Policy. In addition, this Destination contributes to the industrial strategy, the chemicals strategy for sustainability, the European Climate Law, the SME strategy, the communication on safe and sustainable by design framework, the sustainable blue economy and its offshoot initiatives, the EU biodiversity strategy for 2030, the EU Nature Restoration Regulation, the proposals for an EU forest monitoring regulation and a directive on EU soil monitoring and resilience.
The Destination also upholds the upcoming working plan for the implementation of Ecodesign for Sustainable Products Regulation and research needs identified in the Global Resources Outlook 2024. In addition, it supports the EU social economy action plan and the Council Recommendation on developing social economy framework conditions which includes social economy entities in the circular economy.
Furthermore, it will support the EU biotechnology and biomanufacturing initiative, covering and underpinning sustainable bio-based innovation systems, as well as the Commission communication “A Competitive Compass for the EU”, the upcoming strategy for European life sciences and the EU biotech act. Also, it will support the capacity of bio-based systems to enable a sustainable carbon management and allow the better understanding of the carbon removal potential of circular bio-based economies. Through innovative circular and bio-based materials, products, processes and value chains for consumers and industry, the awareness and importance of agriculture and forestry in the EU will be strengthened. The destination will align with the Global Biodiversity Framework, the future science-policy panel to further contribute to the sound management of chemicals and waste and to prevent pollution and promote the new approach for the sustainable blue economy in the EU, which stresses that marine/aquatic biotechnology offers solutions for materials, enzymes, food supplements and pharmaceuticals.
R&I activities under this Destination will help establishing healthy, biodiverse and resilient forests that are sustainably managed and able of providing a wide range of key ecosystem services, including climate mitigation through carbon removals and continuing supplying materials and services for the development of a sustainable forest bioeconomy in line with the EU forest strategy for 2030.
Proposals for topics under this destination should set out a credible pathway contributing to “achieving healthy soils and forests, as well as clean air, fresh and marine water, whilst ensuring water resilience and the transition to a clean, competitive and circular economy and sustainable bioeconomy”, and more specifically to one or more of the following impacts:
- innovative circular and bio-based materials, products, processes and value chains are developed for the consumers and industry, replacing unsustainable alternatives and leading to new and more sustainable approaches for managing waste materials and by-products, aiming at pollution prevention and remediation, and the promotion of new forms of cooperation between diverse economic and societal actors across sectors and territories;
- industry and consumers benefit from new opportunities both through sustainable novel products in line with ecodesign principles, and novel circular business models that have a mitigating impact on resource use and greenhouse gas emissions;
- innovative business and governance models, are advanced to foster safe and sustainable product design. This includes durability, reliability, reusability, upgradability, reparability, recyclability, recycled content, and circularity with a comprehensive approach addressing environmental impacts also at a territorial level and involving civil society in fostering a circular economy;
- large-scale diffusion of social and technological innovation across circular and bioeconomy sectors within planetary boundaries thanks to innovative, socially fair, climate-neutral, circular, bio-based and nature-based solutions;
- the full potential of marine and freshwater biological resources and blue biotechnology is leveraged to deliver societal benefits, such as more environment-friendly industrial products and processes, support public health and environmental conservation;
- actors in the forest sector foster the multi-functionality of forests based on the three pillars of sustainability (economic, environmental and social), enhancing a sustainable and circular bioeconomy including support to business development; restoring and protecting biodiversity and ecosystems, ensuring that ecosystem services continue to be delivered including mitigating and adapting to climate change; and delivering societal expectations including well-being of different actors.
R&I fostering circular economy and other sectors under this Destination aimed at impacting or involving civil society will take into account the participation of disadvantaged groups based on gender and other social categories as appropriate.
The Horizon Europe work programme for 2025 will play a critical role in implementing the Ecodesign for Sustainable Product Regulation (ESPR). More sustainable and circular products will contribute to the resilience and competitiveness of the EU economy. Changes in consumer behaviour and availability of attractive service solutions will lead to waste prevention and tangible reduction in material and energy consumption and greenhouse gas emissions. R&I can link various EU policies, namely those with measures to create market demand for secondary materials related to the green and digital transitions, resilience and competitiveness.
Outcomes will ensure synergies with Cluster 4 – ‘Digital, industry and Space’, its partnerships and with Cluster 5 – ‘Climate, Energy and Mobility’. Full synergy and complementarity will be ensured with the fully operational EU partnership on ‘Circular Bio-based Europe’ (CBE Joint Undertaking), the EU partnership for a climate neutral, sustainable and productive blue economy and with the EU mission ‘Restore our Ocean and Waters by 2030’, as well as with the Soil mission. Furthermore, to maximise the local impact under this destination, synergies and complementarities with the Circular Cities and Regions Initiative (CCRI) and the New European Bauhaus (NEB) Facility are encouraged as appropriate. Coordination will be ensured with the long-standing EC Knowledge Centre for Bioeconomy. Possible synergies should be sought with other JRC activities. The destination will ensure synergies and complementarities with the future European Partnership “Forests and forestry for a sustainable future”. To maximise the impacts of R&I under this Destination, international cooperation is encouraged.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
described in Annex G of the Work Programme General Annexes.
Specific conditions
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA, IA)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
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Latest Updates
PROPOSAL NUMBERS
Call HORIZON-CL6-2025-01 has closed on 17/09/2025
515 proposals have been submitted.
The breakdown per topic is:
·HORIZON-CL6-2025-01-BIODIV-01 : 1
·HORIZON-CL6-2025-01-BIODIV-02 : 15
·HORIZON-CL6-2025-01-BIODIV-03 : 11
·HORIZON-CL6-2025-01-BIODIV-04 : 22
·HORIZON-CL6-2025-01-BIODIV-05 : 24
·HORIZON-CL6-2025-01-BIODIV-06 : 19
·HORIZON-CL6-2025-01-BIODIV-07 : 17
·HORIZON-CL6-2025-01-BIODIV-08 : 11
·HORIZON-CL6-2025-01-BIODIV-09 : 23
·HORIZON-CL6-2025-01-BIODIV-10 : 26
·HORIZON-CL6-2025-01-CIRCBIO-01 : 35
·HORIZON-CL6-2025-01-CIRCBIO-02 : 11
·HORIZON-CL6-2025-01-CIRCBIO-03 : 13
·HORIZON-CL6-2025-01-CIRCBIO-04 : 9
·HORIZON-CL6-2025-01-CIRCBIO-05 : 17
·HORIZON-CL6-2025-01-CIRCBIO-06 : 21
·HORIZON-CL6-2025-01-CIRCBIO-07 : 22
·HORIZON-CL6-2025-01-CIRCBIO-08 : 25
·HORIZON-CL6-2025-01-CIRCBIO-09 : 15
·HORIZON-CL6-2025-01-CIRCBIO-10 : 3
·HORIZON-CL6-2025-01-CIRCBIO-11 : 5
·HORIZON-CL6-2025-01-CIRCBIO-12 : 2
·HORIZON-CL6-2025-01-CIRCBIO-13 : 21
·HORIZON-CL6-2025-01-CIRCBIO-14 : 12
·HORIZON-CL6-2025-01-CIRCBIO-15 : 2
·HORIZON-CL6-2025-01-ZEROPOLLUTION-01 : 16
·HORIZON-CL6-2025-01-ZEROPOLLUTION-02 : 3
·HORIZON-CL6-2025-01-ZEROPOLLUTION-03 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-04 : 9
·HORIZON-CL6-2025-01-ZEROPOLLUTION-05 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-06 : 19
·HORIZON-CL6-2025-01-ZEROPOLLUTION-07 : 16
Evaluation results are expected to be communicated in January 2026.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved. In addition to the information published in the topic page, you can always find a full description of the 7 destinations (Biodiversity and ecosystem services; Fair, healthy and environment-friendly food systems from primary production to consumption; Circular economy and bioeconomy sectors; Clean environment and zero pollution; Land, ocean and water for climate action; Resilient, inclusive, healthy and green rural, coastal and urban communities; Innovative governance, environmental observations and digital solutions in support of the Green Deal) that are relevant for the call in the Work Programme 2025 part for “Food, Bioeconomy, Natural Resources, Agriculture and Environment”. Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.