Bioprospecting and optimized production of the terrestrial natural products: new opportunities for bio-based sectors
HORIZON Innovation Actions
Basic Information
- Identifier
- HORIZON-CL6-2025-01-CIRCBIO-08
- Programme
- Cluster 6 Call 01 - single stage
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- May 6, 2025
- Deadline
- September 17, 2025
- Deadline Model
- single-stage
- Budget
- €2,000,000
- Min Grant Amount
- €2,000,000
- Max Grant Amount
- €2,000,000
- Expected Number of Grants
- 1
- Keywords
- HORIZON-CL6-2025-01-CIRCBIO-08HORIZON-CL6-2025-01Agricultural biotechnologyBiochemical research methodsBiochemistry and molecular biologyBiochemistry and molecular mechanisms of signal transductionBiodiversity conservationBiological chemistryCell biology, MicrobiologyChemical sciencesComputer and information sciencesEnvironmental biotechnologyEnvironmental engineeringIPR managementMolecular biologyPlant sciences, botanyTechnology management
Description
Successful proposals should contribute to a clean, competitive and circular economy and sustainable bioeconomy, through the integration of bioprospecting/biodiscovery, biotechnology and biomanufacturing, enabling the deployment of innovative circular and climate-neutral bio-based materials, processes and value chains with higher resource efficiency and market value.
Project results are expected to contribute to all of the following expected outcomes:
- demonstrating the broadened range of more sustainable and more accessible natural bio-based products from terrestrial ecosystems with high value market applications;
- demonstrating advances in the development and/or application of related computational tools and methods or technologies, such as AI etc. in the biodiscovery pipeline;
- increased commitment to biodiversity preservation and conservation through enabling bioproduction routes (biosynthesis, fermentation, culturing) of natural products, ensuring that the biodiscovery of new compounds does not lead to unsustainable harvesting from the wild, to ensure a sustainable use of genetic diversity;
- awareness raising and creation of a better framework for biotechnology and bio-based innovation and uptake through broad stakeholder engagement, supporting the EU biotechnology and biomanufacturing initiative.
The action covers modern biodiscovery approaches, including full integration of digital-driven, ‘-omics’ and associated bioinformatic tools[1], which make possible the identification and further upscaling (optimized production) of bioactive natural compounds with potential high-value application in various bio-based sectors including pharmaceuticals, nutraceuticals, cosmetics, food/feed additives, agrochemicals, cleaning etc. In the context of this topic, the natural products are understood as biologically active products such as secondary metabolites as well as enzymes derived from terrestrial organisms. New products should be safe and sustainable following the SSbD approach.[2]
The scope covers immense diversity of terrestrial micro- and macro-organisms and their communities, which represents a rich and largely unexplored reservoir of natural products and their base ingredients (e.g. plants, fungi, microorganisms etc are in scope. The biochemical interplay between interspecies communities, e.g. symbiotic or defence mechanisms may offer attractive leads and is also in scope). For the coverage of aquatic bioprospecting see parallel topic HORIZON-CL6-2025-01-CIRCBIO-14: Bioprospecting of marine natural products in the -omics & artificial intelligence era.
The aim of this action is to broaden the range of novel compounds, lowering the production costs, quicken the development pipeline, and enable more innovation for the industrial operators, with clear-cut benefits for the final users (consumers and industries). The biodiscovery pipeline may cover in silico prospecting, genomic characterisation, creation of natural product libraries, bioactivity screening, chemical structure elucidation, natural products isolation and purification, and/or optimized production pathways via biotechnology and biomanufacturing approaches (including via gene editing) in suitable industrial facilities (bioreactors/biorefineries, e.g. microbial production), or synthetic biology approaches.
Targeted terrestrial biological resources can be sourced from their natural environment (in-situ) and/or from public and private collections and gene-banks (ex-situ).
The integration of digital approaches and tools (AI, computer algorithms such as machine learning, modelling, data science, digital twins etc) on optimizing the biodiscovery processes such as identification of biosynthetic gene clusters and metabolic pathways, enzyme selection, combinatorial assembly and annotation of high-throughput DNA sequencing data, bioactivity prediction, elucidation of the structure of compounds, experimental design etc is in scope (see the parallel topic HORIZON-CL6-2025-01-CIRCBIO-09: Unleashing the potential and advancing the impact of the digitalization/AI of the bio-based value chains).
Safety to the end-users, and operators needs to be assessed and guaranteed.
The action needs to avoid overlaps to past or ongoing topics (e.g. projects funded under the topic HORIZON-CL6-2022-CIRCBIO-02-05-two-stage - Life sciences and their convergence with digital technologies for prospecting, understanding and sustainably using biological resources, or the topic HORIZON-CL6-2023-CIRCBIO-01 - Broadening the spectrum of robust enzymes and microbial hosts in industrial biotechnology), consider synergies to parallel actions (e.g. HORIZON-CL6-2025-01-CIRCBIO-14 - Bioprospecting of marine natural products in the omics and artificial intelligence era), as well as funded under topic HORIZON-2020-FNR-11-2020: Prospecting aquatic and terrestrial natural biological resources for biologically active compounds[3]. Also, links to the actions under the Circular Bio-based Europe Joint Undertaking (CBE JU) may be established, as relevant.
Proposals should take into account the findings of the Global Resources Outlook 2024 of the International Resource Panel.
Projects will have a strong industry/SME focus and include demonstration activities to proof the techno/economic viability of the production of the proposed terrestrial natural product(s) and/or the biodiscovery platform tools combining digital approaches and tools and biotechnologies.
The action needs to guarantee biodiversity preservation. This can be addressed, inter alia, by covering propagation of biological material, including by in vitro cultivation, as well as by biotechnological approaches. The aim is to decrease of pressure on wild resources and ensure higher overall sustainability, with policy dialogue with competent authorities; projects need to comply with applicable EU regulations and international rules on access to biological resources, such as UN Convention on Biological Diversity and its Nagoya Protocol, their sustainable use and the fair and equitable sharing of benefits from their utilisation. A sustainability assessment should be carried out to evaluate the environmental, economic and social performance of the developed product(s). Proposals should contribute to understanding of potential trade-offs inherent in the exploitation of ecosystems, and their potential to deliver ecosystem services. Any risks to the ecosystems should be assessed and minimised, along the application of the Do-No-Significant-Harm (DNSH) principle.
Proposals should include a task dedicated to sharing methodologies and findings with projects funded under this topic and with similar recent or ongoing projects.
International cooperation is encouraged, for win-win outcomes and mutual benefits.
[1] Related to e.g. statistics, algorithms, AI, data science, modelling etc.
[2] Commission Recommendation (EU) 2022/2510 of 8 December 2022 establishing a European assessment framework for ‘safe and sustainable by design’ chemicals and materials.
[3] https://cordis.europa.eu/programme/id/H2020_FNR-11-2020/en.
Destination & Scope
Under Destination “Circular economy and bioeconomy sectors’, R&I in 2025 provides scientific and technological support to the European Green Deal, in line with the new Commission priority on “A new plan for Europe’s sustainable prosperity and competitiveness”.
Actions focus on the implementation of a wide range of EU initiatives such as the circular economy action plan and the upcoming Circular Economy Act, the EU bioeconomy strategy and its upcoming update, the forest strategy for 2030, and the Common Agriculture Policy. In addition, this Destination contributes to the industrial strategy, the chemicals strategy for sustainability, the European Climate Law, the SME strategy, the communication on safe and sustainable by design framework, the sustainable blue economy and its offshoot initiatives, the EU biodiversity strategy for 2030, the EU Nature Restoration Regulation, the proposals for an EU forest monitoring regulation and a directive on EU soil monitoring and resilience.
The Destination also upholds the upcoming working plan for the implementation of Ecodesign for Sustainable Products Regulation and research needs identified in the Global Resources Outlook 2024. In addition, it supports the EU social economy action plan and the Council Recommendation on developing social economy framework conditions which includes social economy entities in the circular economy.
Furthermore, it will support the EU biotechnology and biomanufacturing initiative, covering and underpinning sustainable bio-based innovation systems, as well as the Commission communication “A Competitive Compass for the EU”, the upcoming strategy for European life sciences and the EU biotech act. Also, it will support the capacity of bio-based systems to enable a sustainable carbon management and allow the better understanding of the carbon removal potential of circular bio-based economies. Through innovative circular and bio-based materials, products, processes and value chains for consumers and industry, the awareness and importance of agriculture and forestry in the EU will be strengthened. The destination will align with the Global Biodiversity Framework, the future science-policy panel to further contribute to the sound management of chemicals and waste and to prevent pollution and promote the new approach for the sustainable blue economy in the EU, which stresses that marine/aquatic biotechnology offers solutions for materials, enzymes, food supplements and pharmaceuticals.
R&I activities under this Destination will help establishing healthy, biodiverse and resilient forests that are sustainably managed and able of providing a wide range of key ecosystem services, including climate mitigation through carbon removals and continuing supplying materials and services for the development of a sustainable forest bioeconomy in line with the EU forest strategy for 2030.
Proposals for topics under this destination should set out a credible pathway contributing to “achieving healthy soils and forests, as well as clean air, fresh and marine water, whilst ensuring water resilience and the transition to a clean, competitive and circular economy and sustainable bioeconomy”, and more specifically to one or more of the following impacts:
- innovative circular and bio-based materials, products, processes and value chains are developed for the consumers and industry, replacing unsustainable alternatives and leading to new and more sustainable approaches for managing waste materials and by-products, aiming at pollution prevention and remediation, and the promotion of new forms of cooperation between diverse economic and societal actors across sectors and territories;
- industry and consumers benefit from new opportunities both through sustainable novel products in line with ecodesign principles, and novel circular business models that have a mitigating impact on resource use and greenhouse gas emissions;
- innovative business and governance models, are advanced to foster safe and sustainable product design. This includes durability, reliability, reusability, upgradability, reparability, recyclability, recycled content, and circularity with a comprehensive approach addressing environmental impacts also at a territorial level and involving civil society in fostering a circular economy;
- large-scale diffusion of social and technological innovation across circular and bioeconomy sectors within planetary boundaries thanks to innovative, socially fair, climate-neutral, circular, bio-based and nature-based solutions;
- the full potential of marine and freshwater biological resources and blue biotechnology is leveraged to deliver societal benefits, such as more environment-friendly industrial products and processes, support public health and environmental conservation;
- actors in the forest sector foster the multi-functionality of forests based on the three pillars of sustainability (economic, environmental and social), enhancing a sustainable and circular bioeconomy including support to business development; restoring and protecting biodiversity and ecosystems, ensuring that ecosystem services continue to be delivered including mitigating and adapting to climate change; and delivering societal expectations including well-being of different actors.
R&I fostering circular economy and other sectors under this Destination aimed at impacting or involving civil society will take into account the participation of disadvantaged groups based on gender and other social categories as appropriate.
The Horizon Europe work programme for 2025 will play a critical role in implementing the Ecodesign for Sustainable Product Regulation (ESPR). More sustainable and circular products will contribute to the resilience and competitiveness of the EU economy. Changes in consumer behaviour and availability of attractive service solutions will lead to waste prevention and tangible reduction in material and energy consumption and greenhouse gas emissions. R&I can link various EU policies, namely those with measures to create market demand for secondary materials related to the green and digital transitions, resilience and competitiveness.
Outcomes will ensure synergies with Cluster 4 – ‘Digital, industry and Space’, its partnerships and with Cluster 5 – ‘Climate, Energy and Mobility’. Full synergy and complementarity will be ensured with the fully operational EU partnership on ‘Circular Bio-based Europe’ (CBE Joint Undertaking), the EU partnership for a climate neutral, sustainable and productive blue economy and with the EU mission ‘Restore our Ocean and Waters by 2030’, as well as with the Soil mission. Furthermore, to maximise the local impact under this destination, synergies and complementarities with the Circular Cities and Regions Initiative (CCRI) and the New European Bauhaus (NEB) Facility are encouraged as appropriate. Coordination will be ensured with the long-standing EC Knowledge Centre for Bioeconomy. Possible synergies should be sought with other JRC activities. The destination will ensure synergies and complementarities with the future European Partnership “Forests and forestry for a sustainable future”. To maximise the impacts of R&I under this Destination, international cooperation is encouraged.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
described in Annex G of the Work Programme General Annexes.
Specific conditions
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA, IA)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
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Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
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Latest Updates
PROPOSAL NUMBERS
Call HORIZON-CL6-2025-01 has closed on 17/09/2025
515 proposals have been submitted.
The breakdown per topic is:
·HORIZON-CL6-2025-01-BIODIV-01 : 1
·HORIZON-CL6-2025-01-BIODIV-02 : 15
·HORIZON-CL6-2025-01-BIODIV-03 : 11
·HORIZON-CL6-2025-01-BIODIV-04 : 22
·HORIZON-CL6-2025-01-BIODIV-05 : 24
·HORIZON-CL6-2025-01-BIODIV-06 : 19
·HORIZON-CL6-2025-01-BIODIV-07 : 17
·HORIZON-CL6-2025-01-BIODIV-08 : 11
·HORIZON-CL6-2025-01-BIODIV-09 : 23
·HORIZON-CL6-2025-01-BIODIV-10 : 26
·HORIZON-CL6-2025-01-CIRCBIO-01 : 35
·HORIZON-CL6-2025-01-CIRCBIO-02 : 11
·HORIZON-CL6-2025-01-CIRCBIO-03 : 13
·HORIZON-CL6-2025-01-CIRCBIO-04 : 9
·HORIZON-CL6-2025-01-CIRCBIO-05 : 17
·HORIZON-CL6-2025-01-CIRCBIO-06 : 21
·HORIZON-CL6-2025-01-CIRCBIO-07 : 22
·HORIZON-CL6-2025-01-CIRCBIO-08 : 25
·HORIZON-CL6-2025-01-CIRCBIO-09 : 15
·HORIZON-CL6-2025-01-CIRCBIO-10 : 3
·HORIZON-CL6-2025-01-CIRCBIO-11 : 5
·HORIZON-CL6-2025-01-CIRCBIO-12 : 2
·HORIZON-CL6-2025-01-CIRCBIO-13 : 21
·HORIZON-CL6-2025-01-CIRCBIO-14 : 12
·HORIZON-CL6-2025-01-CIRCBIO-15 : 2
·HORIZON-CL6-2025-01-ZEROPOLLUTION-01 : 16
·HORIZON-CL6-2025-01-ZEROPOLLUTION-02 : 3
·HORIZON-CL6-2025-01-ZEROPOLLUTION-03 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-04 : 9
·HORIZON-CL6-2025-01-ZEROPOLLUTION-05 : 35
·HORIZON-CL6-2025-01-ZEROPOLLUTION-06 : 19
·HORIZON-CL6-2025-01-ZEROPOLLUTION-07 : 16
Evaluation results are expected to be communicated in January 2026.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved. In addition to the information published in the topic page, you can always find a full description of the 7 destinations (Biodiversity and ecosystem services; Fair, healthy and environment-friendly food systems from primary production to consumption; Circular economy and bioeconomy sectors; Clean environment and zero pollution; Land, ocean and water for climate action; Resilient, inclusive, healthy and green rural, coastal and urban communities; Innovative governance, environmental observations and digital solutions in support of the Green Deal) that are relevant for the call in the Work Programme 2025 part for “Food, Bioeconomy, Natural Resources, Agriculture and Environment”. Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.