Land-based bioprospecting and production of bioactive compounds and functional materials for multiple bio-based value chains
HORIZON Research and Innovation Actions
Basic Information
- Identifier
- HORIZON-CL6-2023-CircBio-01-4
- Programme
- Circular economy and bioeconomy sectors
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- December 22, 2022
- Deadline
- March 28, 2023
- Deadline Model
- single-stage
- Budget
- €12,000,000
- Min Grant Amount
- €6,000,000
- Max Grant Amount
- €6,000,000
- Expected Number of Grants
- 2
- Keywords
- HORIZON-CL6-2023-CircBio-01-4HORIZON-CL6-2023-CIRCBIO-01Agricultural biotechnologyBiochemistryBiochemistry and molecular biologyBiodiversity conservationBiological sciencesIndustrial dynamicsPlant sciences, botany
Description
A successful proposal will contribute to all Destination ‘Circular economy and bioeconomy sectors’ impacts related to consumers and industry, in particular to development of innovative and sustainable value-chains in the bio-based sectors and of European industrial sustainability, competitiveness and EU resource independence / strategic autonomy. It will also contribute via research on biotechnology and other enabling technologies, as a prerequisite and driver of future solutions for the bioeconomy transition.
Project results are expected to contribute to all of the following outcomes:
- Enhanced understanding of terrestrial biodiversity and the limits and potentials of its valorisation;
- Addressing the need of sustainable sourcing and development of novel natural, sustainable and ‘eco-friendly’ (including ‘climate-friendly’) materials and product ingredients for various sectors and applications. These will eventually deliver clear-cut benefits for consumers by being more effective and/or eco-friendly, cheaper, better for climate, and more readily accessible than existing fossil-based alternatives;
- Improved sustainable exploitation, cultivation and processing methods based on promising species/organisms (including complex inter-species communities), and chosen production routes; leading to a diminished pressure on the natural resources (especially biodiversity) in situ.
- Increased competitiveness of European biotechnology, in particular the SMEs sector.
- Increased public knowledge and awareness of connections between biodiversity and biotechnology and its potentials, leading to increased trust in the scientific approaches based on informed and robust communication and mutual-learning efforts.
Global terrestrial biodiversity remains a largely untapped source of natural bioactive molecules and compounds, often combined with interesting potential functional properties of high economic and social value. Such chemical diversity and structural complexity may be matched with biological potency and selectivity. While some of the natural biochemical diversity has been studied[1], the potential for developing new applications and products is far from exhausted[2]. There are still significant opportunities to improve the biodiscovery process as well as understanding of specific biochemical pathways leading to high-value applications, especially with those with a reduced Green House Gas (GHG) emissions, in various sectors, based on novel biochemicals and functional bio-based materials.
This will increase capacity in the European biotechnology sector and other industries to respond to society’s needs. The challenge is to match sustainable sourcing and processing with efficient and cost-effective use. This calls for close cooperation between industrial and academic partners, with due consideration for health/safety and environmental legislation, and informed public engagement.
Activities should address:
- Technical improvements of the bioprospecting of any land-based organisms for potential bioactive compounds and functional materials, based on identified suitable sources of feedstock. The bioprospecting may be “bio-guided” by the study of chemical ecology interspecific interactions (symbiotic/defence) such as, for instance, plant-insects, or microbial-insect/plant/fungus interactions.
- Addressing sustainable biodiscovery, including by advanced detection methods, such as in silico database analysis, microfluidics/lab-on-chip, high-throughput screening, machine learning, etc, overcoming the issues of low concentrations of target molecules, and their general scarcity, and use of natural biological resources from diverse terrestrial environments and ecosystems, allowing better assessment of the selected bioactivity/functional property potential.
- Defining and assessing the optimal further production routes via innovative approaches and systems/platforms (e.g., biotechnology, hydroponics, bioreactors), as well as economic feasibility assessment of these options for resulting bioactive compounds and functional materials, ensuring full valorisation of biomass and all by-products in the production routes, and biomass’ sustainable supply, and, if appropriate, proposing an outline of continuation of the end-product development beyond the project timeline and its present resources.
- Assessing and clearly communicating, by inclusive communication and dissemination strategies, the environmental and climate benefits (e.g., by lowering the pressure on the natural habitats (decrease of harvesting in situ), supporting nature conservation, and increase overall resource efficiency and sustainability), while expanding the range of natural ingredients for the new applications in industrial sectors.
- Covering the environmental, climate and safety/health impacts of the developed ingredients or processes, using Life-Cycle Assessment (LCA) methodologies based on available standards, certification, and accepted and validated approaches. Estimate of possible negative environmental impacts and trade-offs should be provided. The need to guarantee biodiversity preservation and compliance with relevant international rules on access to biological resources, their sustainable use and the fair and equitable sharing of benefits from their utilisation, with the national regulations in the source countries and with the Convention on Biological Diversity and its Nagoya Protocol.
- Food, biofuel and bioenergy applications are not in scope. Agricultural crop protection products (chemical pesticide substitutes) are also not in scope, to avoid overlaps with a parallel topic[3]. Marine and aquatic ecosystems are also out of scope to avoid overlap with parallel topics[4] and projects funded under the recent call[5]. For any health-related applications, complementarities with Horizon Europe Cluster 1 ‘Health’ should be carefully explored, to avoid duplications, and seek synergies.
Where relevant, and to increase impact, proposals should seek links and synergies as well as capitalise on the results of past and ongoing research projects[6] (including under the Bio-based Industries Joint Undertaking (BBI JU) / Circular Bio-based Europe Joint Undertaking (CBE JU)).
In this topic the integration of the gender dimension (sex and gender analysis) in research and innovation content is not a mandatory requirement.
[1] E.g., Horizon 2020 topic FNR-11-2020. Prospecting aquatic and terrestrial natural biological resources for biologically active compounds, ongoing project InnCoCells.
[2] European Commission, Directorate-General for Research and Innovation, Wydra, S., Hüsing, B., Aichinger, H., et al, Life and biological sciences and technologies as engines for bio-based innovation, Publications Office, 2021, https://data.europa.eu/doi/10.2777/046454.
[3] HORIZON-CL6-2023-FARM2FORK-01-7: Innovations in plant protection: alternatives to reduce the use of pesticides focusing on candidates for substitution.
[4] Topics under the present Destination, Heading 3 – Innovating for blue bioeconomy and biotechnology value chains.
[5] Horizon 2020 topic FNR-11-2020-(B). Prospecting aquatic and terrestrial natural biological resources for biologically active compounds, projects MARBLES, SECRETed, ALGAE4IBD.
[6] Horizon 2020 topic FNR-11-2020-(A). Prospecting aquatic and terrestrial natural biological resources for biologically active compounds, project InnCoCells.
Destination & Scope
This destination and its topics target climate-neutrality, zero pollution[1], fair and just circular and bioeconomy transitions[2]. These cover safe, integrated circular solutions at territorial and sectoral levels, for important material flows and product value chains, such as i) textiles, ii) electronics, iii) chemicals, iv) packaging, v) tourism, vi) plastics and construction, and vii) key bioeconomy sectors such as a) sustainable bio-based systems[3], b) sustainable forestry, c) small-scale rural bio-based solutions, d) environmental services and e) aquatic (including marine and freshwater) value chains[4].
The destination supports the European Green Deal, and in particular:
- the new EU Circular Economy Action Plan (CEAP), adopted in March 2020, and the subsequent initiatives along the entire life cycle of products[5];
- the EU strategy on adaptation to climate change adopted in February 2021[6];
- the EU zero pollution action plan[7], adopted in May 2021, with the chemicals strategy for sustainability[8] from October 2020 and the new approach for a sustainable blue economy[9] adopted in May 2021;
- the EU forest strategy for 2030[10]: research and innovation will be key drivers in achieving the ambitious goals of this strategy;
- the EU climate law targeting climate-neutrality by 2050 and AFOLU[11] climate-neutrality by 2035, which supports increased focus on bio-based circular consumption, as part of the Fit for 55 package proposed on 14 July 2021[12];
- the new European Bauhaus initiative[13] and the renovation wave[14].
Furthermore, the Horizon Europe work programme for 2023-2025 of will play a critical role in implementing the EU strategy for sustainable textiles[15], which highlights the strategic role Horizon Europe initiatives play in R&I in the textile ecosystem. Textiles are the fourth highest category as regards pressure on the use of primary raw materials and water and fifth for GHG emissions, and are a major source of microplastic pollution in production and use phases. They are also a key material and product stream in the circular economy action plan. Improvements in the circularity of the textile value chains will help reduce GHG emissions and environmental pressure. The framework is established in the strategy for sustainable textiles, The transition pathway is a multistakeholder process, that could support implementation Attention should be paid to ensuring a circular, safe and sustainable design and the use of new sustainable biobased materials, as well as to collection, sorting and upcycling. Automated processes and digital solutions should help increase reuse and recycling. The safe-and sustainable-by-design concept aligns circular, safety and bioeconomy approaches with zero pollution. R&I can link various EU policies, namely those related to the green and digital transition, resilience and competitiveness. Under the proposed Ecodesign Sustainable Product Regulation (SPI)[16] the Commission will set out ecodesign requirements on design in order to reduce the environmental footprint of products, striving for products to be kept in circular use for as long as possible.
The wide range of EU initiatives supported by this destination includes:
- the industrial strategy;
- the EU chemicals strategy for sustainability;
- the SME strategy;
- the revised (2018) bioeconomy strategy[17] and its action plan;
- the communication on sustainable carbon cycles;
- the sustainable blue economy approach and its offshoot initiatives;
- the EU biodiversity strategy for 2030;
- the farm to fork strategy;
- the upcoming EU agenda for tourism;
- the plastics strategy and the action plan on critical raw materials.
In addition, this destination will contribute to the transition pathways of energy-intensive industries, textiles, construction and agri-food industrial ecosystems.
Where appropriate, proposals are encouraged to cooperate with the European Commission Knowledge Centre for Bioeconomy, also for the purpose of dissemination and exploitation of results.
Expected impact
Proposals for topics under this destination should set out a credible pathway to:
- develop the circular economy and bioeconomy sectors;
- ensure natural resources are used and managed in sustainable and circular manner;
- prevent and remove pollution;
- unlock the full potential and benefits of the circular economy and the bioeconomy, with clean secondary raw materials, ensuring competitiveness and guaranteeing healthy soil, air, fresh and marine water for all, through better understanding of planetary boundaries and wide deployment and market uptake of innovative technologies and other solutions, notably in primary production (forestry) and bio-based systems.
More specifically, the proposed topics should contribute to one or more of the following impacts:
- Regional, rural, local/urban and consumer-based transitions are accelerated towards a sustainable, regenerative, inclusive, just and clean circular economy and bioeconomy across all regions of Europe. Special attention should be paid to the most sensitive/vulnerable[18] and greenhouse gas-intensive regions, based on better knowledge and understanding of science, and improved capacity to design, implement and monitor policies and instruments for circular and bio-based transitions.
- European industrial sustainability, competitiveness and resource independence are strengthened by reducing the use of primary non-renewable raw materials and greenhouse gases emissions and other pollutants, achieving an improved environmental footprint (including on biodiversity), enabling climate-neutrality, zero pollution[1] and higher resource efficiency. This will also be supported by increasing circular and bio-based practices in textiles, plastics, electronics and construction, developing further on industrial symbiosis as well as circularity and sustainability by design, cascading use of biomass and, clean secondary raw materials, along and across value chains.
- Innovative and sustainable value-chains are developed in the bio-based sectors replacing fossil-based value chains, increasing circular bio-based systems from sustainably sourced biological resources, and replacing carbon-intensive and fossil-based systems. Such a development will be supported through R&I in biotechnology and other enabling technologies, which is a prerequisite and driver of future solutions for a circular economy and the bioeconomy transition. This will involve with inclusive engagement with all stakeholders, including policymakers and will increase access to finance and technical support along whole supply chains for bioeconomy projects.
- The benefit for consumers and citizens, including those in rural areas, are improved by establishing circular and bio-based systems based on sustainability, inclusiveness, zero pollution[1], health and safety. All value chain actors (manufacturers, retailers, service industry, consumers, public administration, including on regional level, primary biomass producers etc.) are involved to a significantly higher degree.
- Multi-functionality and management of forests in Europe are safeguarded based on the three pillars of sustainability (economic, environmental and social), in particular to optimise the contribution of forests and the forest-based sector in mitigating and adapting to climate change.
- Potential of marine and freshwater biological resources and blue biotechnology is enlarged to i) deliver greener (climate-neutral and circular) industrial products and processes, ii) help characterise, monitor and sustain the health of aquatic ecosystems for a healthy planet and people, and iii) help in the drafting of proposals for accompanying changes in regulation where necessary.
[1] See also Destination 4 ‘Clean environment and Zero pollution’ of this Cluster.
[2] Synergies ensured with Horizon Europe Clusters 4 and 5 (including their European public private partnerships), while Cluster 4 targets the industrial dimension (including digitalisation, circularity and climate-neutrality / low GHGs emissions industry transition, including developing bio-integrated manufacturing). Cluster 5 covers cost-efficient, net zero-GHGs energy systems, centred on renewables (including the R&I needed to reduce CO2 emissions from the power and energy-intensive industry sectors, such as solutions for capturing, utilising and storage of CO2 (CCUS), bioenergy/biofuels and other industrial sectors) Cluster 6 covers the research and innovation based on sustainable biological resources (bioeconomy sectors), in particular for new sustainable feedstock development and valorisation through the development of integrated bio-refineries).
[3] In synergy and complementarity with the EU public-private partnership for a ‘Circular Bio-based Europe’ (CBE JU), (especially as related to the size of actions – IAs and RIAs, and Technology Readiness Level and the industrial-focus of activities, with the first CBE calls expected in 2022).
[4] In synergy and complementarity with the EU partnership for a climate-neutral, sustainable and productive blue economy and with the EU mission ‘Restore our Ocean and Waters by 2030’.
[5] It targets how products are designed, promotes circular economy processes, encourages sustainable consumption, and aims to ensure that waste is prevented and the resources used are kept in the economy for as long as possible. This plan also aims to ensure that the circular economy works for people, regions and cities, fully contributes to climate-neutrality, zero pollution and resource use decoupling and harnesses the potential of research, innovation and digitalisation
[6] COM(2021)82 final “Forging a climate-resilient Europe - the new EU Strategy on Adaptation to Climate”.
[7] COM(2021)400 final ‘Pathway to a Healthy Planet for All EU Action Plan: “Towards Zero Pollution for Air, Water and Soil’.
[8] COM(2020) 667 final ‘Chemicals Strategy for Sustainability Towards a Toxic-Free Environment’.
[9] COM(2021)240 final ‘On a new approach for a sustainable blue economy in the EU Transforming the EU's Blue Economy for a Sustainable Future’.
[10] COM(2021)572 final ‘New EU Forest Strategy for 2030’.
[11] AFOLU: “Agriculture, Forestry and Other Land Use”.
[12] COM(2021)550 final “'Fit for 55': delivering the EU's 2030 Climate Target on the way to climate neutrality”.
[13] COM(2021)573 final “New European Bauhaus Beautiful, Sustainable, Together”.
[14] COM(2020)662 final “A Renovation Wave for Europe - greening our buildings, creating jobs, improving lives”.
[15] COM(2022)141 final “EU Strategy for Sustainable and Circular Textiles”.
[16] COM(2022)142 final Proposal for a REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL establishing a framework for setting ecodesign requirements for sustainable products and repealing Directive 2009/125/EC .
[17] European Commission, Directorate-General for Research and Innovation, European bioeconomy policy: stocktaking and future developments: report from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions, Publications Office of the European Union, 2022, https://data.europa.eu/doi/10.2777/997651.
[18] Taking into account all aspects of sustainability, i.e. social, economic and environmental, and in particular sensitivity/vulnerability to the effects of the climate change, as well as due to the current social dependency on fossil resources, especially in remote, rural and low-income regions and cities.
[19] See also Destination 4 ‘Clean environment and Zero pollution’ of this Cluster.
[20] See also Destination 4 ‘Clean environment and Zero pollution’ of this Cluster.
Eligibility & Conditions
General conditions
2. Eligible countries: described in Annex B of the Work Programme General Annexes
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other eligibility conditions: described in Annex B of the Work Programme General Annexes
4. Financial and operational capacity and exclusion: described in Annex C of the Work Programme General Annexes
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Award criteria, scoring and thresholds are described in Annex D of the Work Programme General Annexes
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Submission and evaluation processes are described in Annex F of the Work Programme General Annexes and the Online Manual
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Indicative timeline for evaluation and grant agreement: described in Annex F of the Work Programme General Annexes
6. Legal and financial set-up of the grants: described in Annex G of the Work Programme General Annexes
Specific conditions
7. Specific conditions: described in the [specific topic of the Work Programme]
Documents
Call documents:
Standard application form — call-specific application form is available in the Submission System
Standard application form (HE RIA, IA)
Standard evaluation form — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
MGA
Additional documents:
HE Main Work Programme 2023–2024 – 1. General Introduction
HE Main Work Programme 2023–2024 – 13. General Annexes
HE Framework Programme and Rules for Participation Regulation 2021/695
HE Specific Programme Decision 2021/764
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
Funding & Tenders Portal FAQ – find the answers to most frequently asked questions on submission of proposals, evaluation and grant management.
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The European Charter for Researchers and the Code of Conduct for their recruitment – consult the general principles and requirements specifying the roles, responsibilities and entitlements of researchers, employers and funders of researchers.
Partner Search Services help you find a partner organisation for your proposal.
Latest Updates
CALL UPDATE: FLASH EVALUATION RESULTS
EVALUATION results
Deadline: 28/03/2023
|
Topic Identifier |
Budget |
|
HORIZON-CL6-2023-CircBio-01-13 |
€ 12,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-14 |
€ 4,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-10 |
€ 2,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-1 |
€ 2,500,000.00 |
|
HORIZON-CL6-2023-CircBio-01-2 |
€ 18,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-3 |
€ 2,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-4 |
€ 4,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-5 |
€ 10,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-6 |
€ 3,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-7 |
€ 3,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-8 |
€ 10,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-9 |
€ 8,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-11 |
€ 8,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-12 |
€ 12,000,000.00 |
The results of the evaluation are as follows:
|
Topic Id |
Number of proposals submitted (including proposals transferred from or to other calls) |
Number of inadmissible proposals |
Number of ineligible proposals |
Number of above-threshold proposals |
Total budget requested for above-threshold proposals |
|
HORIZON-CL6-2023-CircBio-01-1 |
2 |
0 |
0 |
1 |
€ 2,613,389.35 |
|
HORIZON-CL6-2023-CircBio-01-10 |
1 |
0 |
0 |
1 |
€ 1,977,398.33 |
|
HORIZON-CL6-2023-CircBio-01-11 |
8 |
0 |
0 |
4 |
€ 15,636,022.50 |
|
HORIZON-CL6-2023-CircBio-01-12 |
5 |
0 |
0 |
4 |
€ 23,421,838.50 |
|
HORIZON-CL6-2023-CircBio-01-13 |
1 |
0 |
0 |
1 |
€ 5,999,675.00 |
|
HORIZON-CL6-2023-CircBio-01-14 |
1 |
0 |
0 |
1 |
€ 4,000,000.00 |
|
HORIZON-CL6-2023-CircBio-01-2 |
3 |
0 |
0 |
2 |
€ 10,992,796.25 |
|
HORIZON-CL6-2023-CircBio-01-3 |
4 |
1 |
0 |
2 |
€ 3,996,585.27 |
|
HORIZON-CL6-2023-CircBio-01-4 |
11 |
0 |
0 |
8 |
€ 31,347,739.00 |
|
HORIZON-CL6-2023-CircBio-01-5 |
8 |
0 |
0 |
4 |
€ 18,422,732.38 |
|
HORIZON-CL6-2023-CircBio-01-6 |
2 |
0 |
0 |
2 |
€ 3,009,473.69 |
|
HORIZON-CL6-2023-CircBio-01-7 |
3 |
0 |
0 |
2 |
€ 2,997,723.25 |
|
HORIZON-CL6-2023-CircBio-01-8 |
14 |
1 |
7 |
3 |
€ 14,782,863.89 |
|
HORIZON-CL6-2023-CircBio-01-9 |
6 |
1 |
1 |
2 |
€ 7,994,451.13 |
We recently informed the applicants about the evaluation results for their proposals.
For questions, please contact the Research Enquiry Service.
CALL UPDATE: PROPOSAL NUMBERS
PROPOSAL NUMBERS
Call HORIZON-CL6-2023-CIRCBIO-01 has closed on the on March 28.
69 proposals have been submitted.
|
Topic Id |
Proposals Received |
|
HORIZON-CL6-2023-CircBio-01-1 |
2 |
|
HORIZON-CL6-2023-CircBio-01-10 |
1 |
|
HORIZON-CL6-2023-CircBio-01-11 |
8 |
|
HORIZON-CL6-2023-CircBio-01-12 |
5 |
|
HORIZON-CL6-2023-CircBio-01-13 |
1 |
|
HORIZON-CL6-2023-CircBio-01-14 |
1 |
|
HORIZON-CL6-2023-CircBio-01-2 |
3 |
|
HORIZON-CL6-2023-CircBio-01-3 |
4 |
|
HORIZON-CL6-2023-CircBio-01-4 |
11 |
|
HORIZON-CL6-2023-CircBio-01-5 |
8 |
|
HORIZON-CL6-2023-CircBio-01-6 |
2 |
|
HORIZON-CL6-2023-CircBio-01-7 |
3 |
|
HORIZON-CL6-2023-CircBio-01-8 |
14 |
|
HORIZON-CL6-2023-CircBio-01-9 |
6 |
Evaluation results are expected to be communicated in July 2023