Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA)
HORIZON Innovation Actions
Basic Information
- Identifier
- HORIZON-CL4-2025-05-MATERIALS-51-two-stage
- Programme
- INDUSTRY two-stage
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- May 22, 2025
- Deadline
- September 23, 2025
- Deadline Model
- two-stage
- Budget
- €13,000,000
- Min Grant Amount
- €6,500,000
- Max Grant Amount
- €6,500,000
- Expected Number of Grants
- 2
- Keywords
- HORIZON-CL4-2025-05-MATERIALS-51-two-stageHORIZON-CL4-2025-05-two-stage
Description
Projects are expected to contribute to the following outcomes:
- Make safer and more sustainable alternatives to per- and poly-fluoroalkyl substances (PFAS) available to industries offering products with targeted performances supporting their competitiveness;
- Give the Commission, regulatory agencies, Member States and associated countries access to new and publicly available knowledge about PFAS alternatives;
- Support EU strategies, policies and legislation, such as future PFAS restrictions under the REACH Regulation[1] , as well as requirements for the EU Ecolabel[2], EU Taxonomy[3] and Eco-design for Sustainable Products Regulation (ESPR)[4], by making safe and sustainable alternatives to PFAS available;
- Demonstrate the applicability of the ‘Safe and Sustainable by Design’ (SSbD) framework[5] to avoid regrettable substitution when developing innovative safe alternatives to PFAS.
PFAS are a large class of substances used in a wide range of applications (for instance, as adhesives, coatings, lubricants, sealants, surfactants), for their technical and/or safety functions (e.g., water and oil repellence, antiadhesion, thermal & chemical stability)[6]. Nevertheless, PFAS have been detected in groundwater, surface water and soil, the remediation of which is extremely problematic[7],[8]. Their accumulation in the environment has been linked to negative effects for the wildlife and the human health, including carcinogenic, mutagenic, reprotoxic and toxic effects for the endocrine system[9]. In January 2023, five national authorities submitted to the European Chemicals Agency (ECHA) a PFAS restriction dossier to ban the manufacture, placing on the market and use of PFAS as a chemical class in all uses, with few exemptions[10].
The Commission initiative for SSbD sets a framework which should be a reference in the proposal. The new alternatives to be developed should meet the technical functions required in the specific applications and align with such framework.
Proposals should address at least one industrial application and should develop one or more new chemical substances or technologies to replace existing PFAS used, according to abovementioned applications and functions, in one of the following areas:
- Electronics, electrical appliances and grids (e.g., wires, cables, heat transfer fluids, transformers, switchgears), where PFAS are currently used to provide a combination of technical and/or safety functions to withstand impact of high temperature, pressure and chemicals, ensure corrosion inhibition and non-flammability.
- Construction technologies (e.g., carpeting, drywall, paintings, foams) where PFAS are currently used to provide a combination of technical functions such as resistance in harsh environments and for wetting agents.
- Technical textiles (e.g., personal protective equipment, construction textiles, filtration and separation media, technical textiles for transport applications) where PFAS are currently used for their repellence but also heat stability and corrosion inhibition.
- Automotive parts (e.g. electrical parts including batteries, membranes, hoses and pipes, brakes, rubber processing) where PFAS are also currently used[11].
All actors along the value chain should be involved to ensure the new substance has a clear use case, market and potential to grow.
Multidisciplinary research activities should address all of the following:
- The ‘Safe and Sustainable by Design’ framework should be applied when developing the alternative(s) and the assessment results be published and underlying methods and data made FAIR across the whole value chain;
- The selection of the PFAS alternatives to be developed should be justified with a technological and socio-economic analysis, also considering potential impacts on health and reproductive health;
- Novel PFAS-free materials or structures should undergo testing under relevant conditions to ensure their properties meet or exceed the properties of PFAS-based solutions across various applications;
- The substitution barriers for the selected applications should be identified and a driving mechanism for a maximal substitution in the targeted value chains proposed;
- Challenges for the adaption of existing production lines should be identified and solutions proposed;
- Communication and other outreach actions to all stakeholders and specifically citizens about the benefits of the developed ‘Safe and Sustainable by Design’ alternatives to PFAS substances.
- Proposals should involve appropriate expertise in Social Sciences and Humanities (SSH), e.g. with communities of citizens to engage in product reliability and consumer rights. At least, an analysis of how the introduction of such alternatives is positively or negatively considered by users and the general population, disruptive (or not) for the established social norms or behavioural patterns, should be conducted;
- Policy briefs will be reported to the European Commission on a yearly basis to communicate on the key results and achievements.
Proposals should indicate to which chapters of the Strategic Research and Innovation Plan for chemicals and materials[12] they will contribute.
Proposals submitted under this topic should include a business case and exploitation strategy.
In accordance with the SSbD framework, this topic requires the effective demonstration of the added value of the outcomes to protect human health and the environment, e.g. in the fields of biodiversity protection, indoor and /or outdoor air quality.
Collaboration with existing Open Innovation Test Beds (OITBs)[13] should be explored - where relevant.
International collaboration is encouraged.
The challenge of developing PFAS alternatives should also cooperate with relevant topics under other clusters and calls of Horizon Europe (e.g. HORIZON-CL4-2021-RESILIENCE-01-08[14], HORIZON-CL4-2022-RESILIENCE-01-23[15], HORIZON-CL6-2023-ZEROPOLLUTION-02-2-two-stage[16], Horizon 2020 LC-GD-8-1-2020[17]), including topics under the Chips Joint Undertaking and the Clean Hydrogen Joint Undertaking (e.g. HORIZON-JTI-CLEANH2-2024-05-02: Development of non-fluorinated components for fuel cells and electrolysers). Proposals should specifically allocate the necessary resources for collaboration with the other relevant projects.
[1] Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02006R1907-20231201
[2] https://ec.europa.eu/environment/ecolabel/the-ecolabel-scheme.html
[3] https://ec.europa.eu/environment/publications/proposal-ecodesign-sustainable-products-regulation_en
[5] See documents defining the SSbD framework and criteria on: https://ec.europa.eu/info/research-and-innovation/research-area/industrial-research-and-innovation/key-enabling-technologies/advanced-materials-and-chemicals_en
[6] This list of applications and functions are not exhaustive, unless explicitly mentioned.
[7] https://www.eea.europa.eu/en/european-zero-pollution-dashboards/indicators/pfas-contamination-and-soil-remediation-signal
[8] PFAS in European seas (Signal) (europa.eu)
[9] https://doi.org/10.2903/j.efsa.2022.e200418
[10] Per- and polyfluoroalkyl substances (PFAS) - ECHA (europa.eu)
[11] The use of (gaseous) PFAS in air conditioning is outside the scope of this call.
Destination & Scope
The research and innovation under this Destination will contribute to a paradigm shift, as regards the availability, development, use and disposal of chemicals and materials. This is necessary to guarantee Europe’s technological sovereignty and capacity to deliver on the twin green and digital transitions (it is thus strongly linked to the objectives of the Destination ‘Achieving global leadership in climate-neutral, circular and digitised industrial and digital value chains’).
To enable such a shift, an innovative, strong European R&I ecosystem for circular chemicals and materials is needed, working across different technology readiness levels. Bringing knowledge and skills together across the materials’ value chains is key to ensuring that this shift can materialise.
The requirements of the European Green Deal for safety, sustainability and circularity should be considered across the life cycle of a chemical or material. The 2022 Commission Recommendation on ‘Safe and Sustainable by Design’ (SSbD) sets out a new framework on how to achieve these objectives.
R&I activities should contribute to strengthen EU’s critical raw materials capacities along all stages of the value chain, increasing our resilience by reducing dependencies, increasing preparedness and promoting supply chain sustainability and circularity, in line with the Critical Raw Materials Act. It is necessary to improve the energy and process efficiency of extractive and processing activities and minimise their environmental impact, including GHG emissions. Advancements need to be made on finding options for replacing critical raw materials with other (advanced) materials offering at least the same functionality and taking into account the existing environmental concerns.
Advanced materials (including amongst others nano- and 2D materials) and chemicals are designed with functionality in mind. Compared to conventional materials, they have novel properties that significantly step-up performance. New digital tools are needed such as common data spaces, digital twins, industrial virtual worlds, as well as novel (autonomous) design, synthesis, development, characterisation and fabrication tools as well as continuous training of scientists on these new tools.
To secure unimpeded market entry, appropriate test methods are needed. New chemicals and materials should be developed using the SSbD framework and with the efficiency and circularity of materials in mind, also for their inclusion in products. This calls for tools, models and data for robust SSbD, including animal-free new approach methodologies and systematic life-cycle assessments. Bio-based advanced materials/chemicals and the integration and interaction of biological and artificial materials and components offer new opportunities to reduce resource dependencies and maintain sustainability.
Achieving the circularity of both raw materials and advanced materials is a key future challenge. Establishing new material flows, recovery, recycling and upcycling of materials from waste are challenges in themselves, but they also require information sharing along and across value chains and development of new business models allowing to foster innovative solutions related to technological progress, such as in materials design.
Uptake of advanced materials as well as a more efficient use of materials should be fostered in product and materials-based technology developments. This also requires new business models to be developed for the deployment of circular technologies and value chains as well as for providing product-as-a-service models, on-demand manufacturing, take-back-schemes and other service-based businesses. Strong support to SMEs is required so they can thrive in this materials ecosystem.
Business cases and exploitation strategies for industrialisation:
This section applies only to those topics in this Destination, for which proposals should demonstrate the expected outcomes by including a business case and exploitation strategy for industrialisation.
A business case and a credible initial exploitation strategy are essential components in the ultimate success of an industry-based project, as well as its prospects to attract further investments for deployment. They will both be decisive factors under the impact criterion, and proposers are encouraged to use the extended page limit to present a carefully considered business case and exploitation strategy, backed by the management of the companies involved.
The business case should demonstrate the expected impact of the proposal in terms of enhanced market opportunities for the participants and deployment in the EU, in the short to medium term. It should describe the targeted market(s); estimated market size in the EU and globally; user and customer needs; and demonstrate that the solutions will match the market and user needs in a cost-effective manner; and describe the expected market position and competitive advantage.
The exploitation strategy should identify obstacles, requirements and necessary actions involved in reaching higher TRLs (Technology Readiness Levels), for example: securing the required investments, including through possible synergies with other programmes; accessing the required skills; matching value chains; enhancing product robustness; securing industrial integrators; and user acceptance.
For TRLs 6 and 7, a credible strategy to achieve future full-scale deployment in the EU is expected, indicating the intentions of the industrial partners after the end of the project.
Where relevant, in the context of skills, it is recommended to develop training material to endow workers with the right skillset in order to support the uptake and deployment of new innovative products, services, and processes developed in the different projects. This material should be tested and be scalable, and can potentially be up-scaled through the European Social Fund Plus (ESF+). This will help the European labour force to close the skill gaps in the relevant sectors and occupational groups and improve employment and social levels across the EU and associated countries.
For topics in this destination, consortia (if selected for funding) could consider voluntary contributions in terms of data, indicators and knowledge to relevant Joint Research Centre (JRC) platforms for capitalising the knowledge developed in their projects and become more policy relevant:
- INnovation Centre for Industrial Transformation and Emissions (INCITE) (https://innovation-centre-for-industrial-transformation.ec.europa.eu/).
- The Energy and Industry Geography Lab: EIGL (https://energy-industry-geolab.jrc.ec.europa.eu/).
Innovation Actions — Legal entities established in China are not eligible to participate in Innovation Actions in any capacity. Please refer to the Annex B of the General Annexes of this Work Programme for further details.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
Applicants submitting a proposal under the blind evaluation pilot (see General Annex F) must not disclose their organisation names, acronyms, logos nor names of personnel in the proposal abstract and Part B of their first-stage application (see General Annex E).
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
This topic is part of the blind evaluation pilot under which first stage proposals will be evaluated blindly.
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025) [[This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’ or through this link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/ls-decision_he_en.pdf]].
described in Annex G of the Work Programme General Annexes.
Specific conditions
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA IA Stage 1 BLIND)
Standard application form (HE RIA IA Stage 1)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA and CSA Stage 1 BLIND)
Standard evaluation form (HE RIA, IA and CSA Stage 1)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Information on financial support to third parties (HE)
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 7. Digital, Industry and Space
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Decision authorising the use of lump sum contributions under the Horizon Europe Programme
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
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Latest Updates
CALL UPDATE: PROPOSAL NUMBERS
PROPOSAL NUMBERS
Call HORIZON-CL4-2025-05-two-stage_stage1 has closed on the 23/09/2025.
243 proposals have been submitted.
The breakdown per topic is:
Topic ID | Topic title | Action type | Proposals submitted |
HORIZON-CL4-2025-05-TWIN-TRANSITION-11-two-stage | Enhanced logistics and operations of construction sites (IA) | IA | 40 |
HORIZON-CL4-2025-05-TWIN-TRANSITION-21-two-stage | Demonstrators for clusters of social circular enterprises (IA) | IA | 8 |
HORIZON-CL4-2025-05-TWIN-TRANSITION-35-two-stage | Developing and embedding upcycling technologies into viable business (Processes4Planet partnership) (IA) | IA | 70 |
HORIZON-CL4-2025-05-MATERIALS-42-two-stage | Innovative Advanced Materials (IAMs) for product monitoring, smart maintenance and repair strategies in the construction sector (RIA) (Innovative Advanced Materials for Europe partnership) | RIA | 54 |
HORIZON-CL4-2025-05-MATERIALS-43-two-stage | Innovative Advanced Materials (IAMs) for robust, fast curing sealants and coatings for manufacturing and final assembly (IA) (Innovative Advanced Materials for Europe partnership) | IA | 42 |
HORIZON-CL4-2025-05-MATERIALS-51-two-stage | Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA) | IA | 29 |
Total: | 243 | ||
Evaluation results are expected to be communicated around 3rd week of December 2025.
A.R.
On Business case and exploitation strategy
Requirement to include Business case and exploitation strategy is applicable only to 2nd stage full applications.
Reminder on proposal part B page limit and formatting conditions
1.Proposal part B page limit
Page limit: The page limit is 10 pages.
The page limit will be applied automatically. At the end of a proposal part B template inside the Submission System you can see the structure of the actual proposal that you need to submit, please remove all instruction pages that are watermarked.
If you attempt to upload a proposal longer than the specified limit before the deadline, you will receive an automatic warning and will be advised to shorten and re-upload the proposal. After the deadline, excess pages (in over-long proposals/applications) will be automatically made invisible, and will not be taken into consideration by the experts. The proposal is a self-contained document. Experts will be instructed to ignore hyperlinks to information that is specifically designed to expand the proposal, thus circumventing the page limit.
Please, do not consider the page limit as a target! It is in your interest to keep your text as concise as possible, since experts rarely view unnecessarily long proposals in a positive light.
2.Proposal part B formatting conditions
The following formatting conditions apply (as listed in a proposal part B template inside the Submission System) and will be checked by the Agency during an admissibility check of submitted proposals.
The reference font for the body text of proposals is Times New Roman (Windows platforms), Times/Times New Roman (Apple platforms) or Nimbus Roman No. 9 L (Linux distributions).
The use of a different font for the body text is not advised and is subject to the cumulative conditions that the font is legible and that its use does not significantly shorten the representation of the proposal in number of pages compared to using the reference font (for example with a view to bypass the page limit).
The minimum font size allowed is 11 points. Standard character spacing and a minimum of single line spacing is to be used. This applies to the body text, including text in tables.
Text elements other than the body text, such as headers, foot/end notes, captions, formula's, may deviate, but must be legible.
The page size is A4, and all margins (top, bottom, left, right) should be at least 15 mm (not including any footers or headers).
Proposal part B template inside the Submission System document is tagged. Do not delete the tags; they are needed for our internal processing of information, mostly for statistical gathering. In that light, please do not move, delete, re-order, alter tags in any way, as they might create problems in our internal processing tools. Tags do not affect or influence the outcome of your application.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved. In addition to the information published in the topic page, you can always find a full description of destinations:
* destination 1: Achieving global leadership in climate-neutral, circular and digitised industrial and digital value chains;
* destination 2: Achieving technological leadership for Europe's open strategic autonomy in raw materials, chemicals and innovative materials,
that are relevant for the call in the Work Programme 2025 part for “Industry”. Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.