Challenge-Driven GenAI4EU Booster (RIA) (AI/Data/Robotics Partnership)
HORIZON Research and Innovation Actions
Basic Information
- Identifier
- HORIZON-CL4-2025-03-DIGITAL-EMERGING-09
- Programme
- DIGITAL - CNECT
- Programme Period
- 2021 - 2027
- Status
- Closed (31094503)
- Opening Date
- June 10, 2025
- Deadline
- October 2, 2025
- Deadline Model
- single-stage
- Budget
- €10,000,000
- Min Grant Amount
- €5,000,000
- Max Grant Amount
- €5,000,000
- Expected Number of Grants
- 2
- Keywords
- HORIZON-CL4-2025-03-DIGITAL-EMERGING-09HORIZON-CL4-2025-03Aeronautical Design and Systems IntegrationArtificial intelligence, intelligent systems, multi agent systemsPharmacodynamicsThe manufacturing aeronautics industry
Description
Project results are expected to contribute to all of the following expected outcomes:
- Significant technology progress and innovation through challenge-driven approach in the fields of aerospace, pharma/drug development or telecommunication networks.
- Increased competitivity and visibility of the Generative AI community in Europe, in demonstrating their capability to achieve challenging tasks within the aerospace, pharma/drug development or telecommunication sectors.
- Increased adoption of Generative AI in aerospace, pharma/drug development or telecommunication networks through tangible progress and achievement demonstrated via the challenge-driven process.
Generative AI (GenAI) promises to transform most industry sectors. This challenge-driven initiative aims to boost both Europe’s developer community and the adoption of powerful trustworthy generative AI solutions in the strategic sectors of aerospace, pharma/drugs and telecommunication networks, key for their competitiveness. In pharmaceuticals, it can, for instance, accelerates drug design by rapidly creating target-specific molecules, reducing development time from years to seconds, and potentially preventing prolonged health crises like COVID-19. In aerospace, generative AI can for instance optimize aircraft design, streamline manufacturing processes, predict maintenance needs through sensor data analysis, route optimisation, and enhance pilot training with diverse, realistic simulations. By embracing generative AI, telecom companies can position themselves at the forefront of a new era of intelligent and automated telecommunications. Specific use-cases include for instance network management, network optimization, network slicing, network healing, predictive maintenance, network mapping and optimization.
Each proposal should focus exclusively on one of the three key sectors mentioned above: aerospace, pharma/drug development, or telecommunications and clearly specify which sector it addresses. Each proposal is expected to focus primarily on the definition, the organization of a multi-stage competition in the chosen sector, as well as the accompanying support to the companies/teams taking part in the challenges, and related activities to maximise the impact of the action.
User industry companies from the strategic sector targeted by the proposal should be core partners in the consortium. They should demonstrate a genuine interest in the projects results and therefore support the challenge participants - in order to reach the most powerful and exploitable results benefitting their industry. The expected results are pre-competitive but the proposal must include a draft exploitation plan outlining commitments on future exploitation. The consortium is responsible for the various stages of the challenges and should provide the necessary support resources during each stage of the competition, including technical assistance and business support to develop an exploitation strategy, but most importantly, provide the data necessary to fine-tune models and build powerful solutions meeting industry needs.
Proposals should be driven by impactful use-cases where generative AI can make the difference: a number of industries from the targeted sector are expected to join forces to define challenging problems to solve with GenAI solutions, which then drive the rest of the project. Based on such challenges, the consortium organises a multi-staged competition with an increasing level of complexity. In the first two stages, third parties, either single companies (typically start-ups or SMEs) or small team of organisations built around such start-ups/SMEs, compete to address the challenges with GenAI solutions. After these stages, the solutions retained for the last stage will be invited to join the consortium, as full beneficiaries.
For each proposal:
- Stage 1: a challenge, open to all, will allow to select for stage 2 the 20 highest ranked solutions, according to a pre-defined selection process and criteria. Each solution competing for the challenge can be submitted either by a single start-up/SME, developer of GenAI solutions, or a small team of organisations built around such start-up/SME
- Stage 2: the 20 solutions selected from stage 1 receive EUR 250 000 FSTP funding, in form of a grant, in order to address the challenge set for this stage by the consortium. At the end of stage 2, the 4 highest ranked competing solutions will be selected for the next stage according to a pre-defined selection process and criteria.
- Stage 3: after the end of stage 2 and the corresponding FSTP scheme, the 4 selected solutions will be invited to join the consortium and receive EUR 2 millions grants each (as part of the eligible costs of the grant agreement) to prepare for the grand finale. The consortium should define measures to maximise the impact for the team winning the grand finale at the end of the third stage, and maximise the uptake of their solutions (for instance, the best performing team could be offered the opportunity to conclude partnerships or contracts with the user industries leading the consortium. Measures to support the broad uptake of their solutions in the whole sector should also be considered).
Such multi-staged scheme is expected to be implemented in parallel by the successful proposals, each addressing a different sector.
Each proposal, involving several major industry players, should define a clear methodology to implement the various steps of the approach, define the specifications of the stages of the competitions, timelines, targets, KPIs, a solid evaluation methodology including evaluation criteria. The main information should be in the proposal, even if refinements could be further developed during the project. The proposers will also be in charge of implementing the evaluation methodology, and providing the necessary infrastructure/technical support for the participants to the challenges. The consortium members are also responsible for ensuring high visibility of the competitions, including possible sponsorships.
The actions selected from this call, each addressing one of the three targeted sectors, are expected to collaborate among themselves, in order to make economies of scale in sharing best practices, defining processes for organising the challenges, ensuring efficient monitoring, organising dissemination and communication activities, etc. Such collaboration among the linked actions is expected to be formalised by a collaboration agreement, after the Grant Agreement signature.
For each proposal, an amount of EUR 5 millions is foreseen to be distributed among the winners of stage 1, in form of FSTP grants, in order to prepare for stage 2. In addition, a budget of EUR 8 millions is reserved in the initial grant, to carry out the stage 3 of the challenge. The proposal is expected to make the case for such investment in defining the objectives with sufficient level of information, even if the details are to be further elaborated in the course of the project. Such amount will be distributed equally among the 4 winning teams of the stage 2, who will be invited to join the consortium as beneficiaries to develop further the solutions and compete for the stage 3 of the challenge.
Visibility would be important; therefore dissemination and communication campaigns are key. The proposers are also encouraged to seek sponsorship, which would be key for the visibility and prestige of their challenge, and to attract the best developers from the EU and associated countries to compete, particularly SMEs and startups, alone or within a team competing for the challenges.
All proposals are expected to incorporate mechanisms for assessing and demonstrating progress, including qualitative and quantitative KPIs, benchmarking, and progress monitoring. This should include the methodology to accompany the challenge participants to the various stages during the project, and the assessment methodology during the various selection stages. As part of the KPIs, efficiency gains from Generative AI should be considered, to maximize broader impact.
When possible, proposals should build on and reuse public results from relevant previous funded actions. Communicable results should be shared with the European R&D community through the AI-on-demand platform, and if necessary, other relevant digital resource platforms to bolster the European AI, Data, and Robotics ecosystem by disseminating results and best practices.
This topic implements the co-programmed European Partnership on AI, data and robotics (ADRA), and all proposals are expected to allocate tasks for cohesion activities with ADRA and the CSA HORIZON-CL4-2025-03-HUMAN-18: GenAI4EU central Hub.
Proposals should also build on or seek collaboration with relevant projects[1] and develop synergies with other relevant International, European, national or regional initiatives.
[1] In particular, proposals in telecommunication should exploit potential synergies with projects funded under HORIZON-CL4-2025-03-DATA-08, HORIZON-CL4-2025-03-DATA-09 and HORIZON-CL4-2025-04-DATA-02; proposals in pharma/drug should exploit potential synergies with relevant projects from Cluster 1 and IHI Innovative Health Initiative; proposals in the aerospace should exploit potential synergies with relevant projects from the clean aviation JU and other similar projects/initiatives.
Destination & Scope
Destination 4 ensures Europe’s strategic autonomy while preserving an open economy in those technologies that will be key for a deep digital transformation of industry, public services and society, while fully playing its enabling role in the twin transition. As set out in the European Chips Act, the top-priorities are to i) strengthen processes undertaken at critical stages in the semiconductor and quantum chips value chain, including chip design and manufacturing technologies, and ii) address the use of new materials and green technologies, energy efficiency and the integration of circularity and life-cycle assessment.
Destination 4 will address high value-added hardware needs for core, cloud and edge, fast-sensing, low-latency and high-bandwidth data transmission, and help secure the supply of critical components for key markets, such as automotive, health, automation and mobility systems. For this purpose, significant human capacity will be required in chip manufacturing to ensure: (i) the strengthening of processes undertaken at critical stages in the value chain; and (ii) that workers can take up quality jobs created as part of these priorities, including through the activities undertaken by the joint undertaking initiative.
In addition, future needs in microelectronics (such as performance, size, cost, energy efficiency, environmental impact, new materials, concepts, architectures, integration) may also be addressed to make sure Europe’s microelectronics industry remains competitive. Opportunities may come from non-volatile memories, spintronics, in-memory computing, neuromorphic and other emerging technologies. Photonics research will lead to fast and versatile sensing and imaging, and energy-efficient building blocks for networks and data centres. The cluster will also push for chip-level integration of photonics and optoelectronics.
The cloud/edge/internet of things will be transformed into an agile and situation-aware infrastructure that brings data to where and when it is needed. Within these smart digital infrastructures, end-to-end artificial intelligence, from the core to the edge and across all technology layers, will be key for on-demand supply of optimal data-, communication-, and computing resource orchestration, with optimal use of energy while preserving privacy and ensuring resilience. European sovereignty in the cloud-edge server market will be strengthened through the power of open-source software, complementing the RISC-V based European Processor Initiative that aims to increase Europe’s independence in high performance computing hardware.
Cluster 4 will transform the user experience. It will push the frontiers of virtual and extended realities (VR/XR) and of open, human-centric virtual worlds for industry, entertainment and arts, public services and people alike, e.g. by leveraging social innovation. It envisages a vibrant R&I ecosystem that strategically joins-up research and development on sophisticated VR/XR optics and displays, multimodal human-computer interaction, authoring tools, real-time spatial computing, rendering, integration and application research. Improved sensing, fast processing and low-latency will be challenging for the underlying cloud/edge/Internet of things. Along similar lines, the way in which the virtual world meets the physical world will continue to evolve, thanks to all kinds of robots and other smart devices that involve self- and context awareness, spatial intelligence, exploiting the best in bias-free AI, engineering and design for game-changing physical characteristics, functional or cognitive capabilities, acute perception, autonomy and safe interaction.
Artificial intelligence underpins many of these changes and Cluster 4 will strengthen and consolidate R&I in this area. For example, today’s generative models are a preview of how virtual worlds and multimodal user-experiences could be produced on-demand. Research on core learning and analysis techniques (incremental, frugal and collaborative), as well as next generation smart robotic systems, will keep Europe at the cutting edge of AI. Artificial Intelligence is also key to keep the competitiveness and strategic autonomy of the EU scientific sector. The EU's comprehensive approach to achieving leadership in AI is reflected in its Apply AI Strategy, which aims at establishing Europe as a global leader in the development and adoption of AI. By fostering a vibrant AI ecosystem, the EU seeks to make Europe a hub for AI innovation and growth, where world-class AI models are developed and integrated into strategic sectors. This initiative is designed to drive innovation, economic growth, and competitiveness, while ensuring that the benefits of AI are shared by all. The topics related to Generative AI included in this destination will support the implementation of the GenAI4EU initiative included in the AI Innovation Package of 24 January 2024. They constitute, moreover, an integral part of the broader Apply AI strategy. By aligning these efforts with the GenAI4EU initiative and the Apply AI strategy, the EU aims to create a cohesive and coordinated approach to AI development and adoption, one that promotes European excellence and leadership in this critical field.
Europe’s long-term competitiveness in the digital area requires continuous scouting and early, low-TRL cross-disciplinary work on new and emerging technologies, dissociated from the main roadmaps. This would encourage collaboration in research and cross-fertilisation between disciplines and sectors on new approaches in: (i) microelectronics; (ii) power electronics; (iii) photonics and photon/phonon/spin/electron integration; (iv) unconventional, hybrid, neuromorphic, nature-inspired or bio-intelligent paradigms; and (v) novel systems and infrastructure architectures.
Europe’s strength in quantum technologies (including in quantum communications and optical satellite communications, etc.) is a strategic asset for its future security and independence. Cluster 4 supports early and mature quantum technologies and stimulates their industrial uptake, e.g. through experimentation and testing environments for integrating them into standard industrial design and manufacturing. Equally transformative, two-dimensional materials (2DM) could positively affect many industries, including ICT. While further exploring the vast range of 2DMs, Cluster 4 will also work towards completing a fully European supply chain and scaling up the development and piloting of 2DM technologies and devices for more industrial fields.
Eligibility & Conditions
General conditions
1. Admissibility Conditions: Proposal page limit and layout
2. Eligible Countries
are described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
In order to achieve the expected outcomes, and safeguard the Union’s strategic assets, interests, autonomy, and security, it is important to avoid a situation of technological dependency on a non-EU source, in a global context that requires the EU to take action to build on its strengths, and to carefully assess and address any strategic weaknesses, vulnerabilities and high-risk dependencies which put at risk the attainment of its ambitions. For this reason, participation is limited to legal entities established in Member States, Iceland and Norway and the following additional associated countries: Canada, Israel, the Republic of Korea, New Zealand, Switzerland, and the United Kingdom.
For the duly justified and exceptional reasons listed in the paragraph above, in order to guarantee the protection of the strategic interests of the Union and its Member States, entities established in an eligible country listed above, but which are directly or indirectly controlled by a non-eligible country or by a non-eligible country entity, may not participate in the action unless it can be demonstrated, by means of guarantees positively assessed by their eligible country of establishment, that their participation to the action would not negatively impact the Union’s strategic assets, interests, autonomy, or security. Entities assessed as high-risk suppliers of mobile network communication equipment within the meaning of ‘restrictions for the protection of European communication networks’ (or entities fully or partially owned or controlled by a high-risk supplier) cannot submit guarantees.[[The guarantees shall in particular substantiate that, for the purpose of the action, measures are in place to ensure that: a) control over the applicant legal entity is not exercised in a manner that retrains or restricts its ability to carry out the action and to deliver results, that imposes restrictions concerning its infrastructure, facilities, assets, resources, intellectual property or know-how needed for the purpose of the action, or that undermines its capabilities and standards necessary to carry out the action; b) access by a non-eligible country or by a non-eligible country entity to sensitive information relating to the action is prevented; and the employees or other persons involved in the action have a national security clearance issued by an eligible country, where appropriate; c) ownership of the intellectual property arising from, and the results of, the action remain within the recipient during and after completion of the action, are not subject to control or restrictions by non-eligible countries or non-eligible country entity, and are not exported outside the eligible countries, nor is access to them from outside the eligible countries granted, without the approval of the eligible country in which the legal entity is established.
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Described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
are described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
To ensure a balanced portfolio covering the different strategic sectors, grants will be awarded to applications not only in order of ranking but at least also to one proposal that is the highest ranked within (i) the aerospace sector, (ii) the pharma/drug development sector, and (iii) the telecommunication sector, provided that the applications attain all thresholds.
Described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
is described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
Grants awarded under this topic will be linked to the other actions granted under this topic. A collaboration agreement will required.
Beneficiaries must provide financial support to third parties. The support to third parties can only be provided in the form of grants. In derogation to article 208 EU Financial Regulation, the maximum amount to be granted to each third party can exceed EUR 60,000 and reach up to EUR 250 000 per competing solution. This derogation is justified by the substantial resources required to successfully carry out the challenges planned in the project in the stage 2, that should be substantiated in the proposals. This amount is granted at the end of the first stage of the challenge to the 20 winning solutions, as a grant to prepare for the stage 2 of the challenge.
Each competing solution to be developed in stage 2 is proposed either by a single start-up/SME or a small team of organisations built around such start-up/SME, therefore the EUR 250 000 is distributed accordingly.
Described in Annex G of the Work Programme General Annexes.
Specific conditions
are described in the specific topic of the Work Programme.
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE RIA, IA)
Evaluation form templates — will be used with the necessary adaptations
Standard evaluation form (HE RIA, IA)
Guidance
Model Grant Agreements (MGA)
Call-specific instructions
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 7. Digital, Industry and Space
HE Main Work Programme 2025 – 14. General Annexes
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
EU Grants AGA — Annotated Model Grant Agreement
Funding & Tenders Portal Online Manual
Support & Resources
Online Manual is your guide on the procedures from proposal submission to managing your grant.
Horizon Europe Programme Guide contains the detailed guidance to the structure, budget and political priorities of Horizon Europe.
Funding & Tenders Portal FAQ – find the answers to most frequently asked questions on submission of proposals, evaluation and grant management.
Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.
National Contact Points (NCPs) – get guidance, practical information and assistance on participation in Horizon Europe. There are also NCPs in many non-EU and non-associated countries (‘third-countries’).
Enterprise Europe Network – contact your EEN national contact for advice to businesses with special focus on SMEs. The support includes guidance on the EU research funding.
IT Helpdesk – contact the Funding & Tenders Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.
European IPR Helpdesk assists you on intellectual property issues.
CEN-CENELEC Research Helpdesk and ETSI Research Helpdesk – the European Standards Organisations advise you how to tackle standardisation in your project proposal.
The European Charter for Researchers and the Code of Conduct for their recruitment – consult the general principles and requirements specifying the roles, responsibilities and entitlements of researchers, employers and funders of researchers.
Partner Search help you find a partner organisation for your proposal.
Latest Updates
In the follow-up of questions raised by applicants, the Commission has identified issues within the call text that may affect the legal certainty of conditions foreseen and a fair evaluation process under the topic HORIZON-CL4-2025-03-DIGITAL-EMERGING-09: Challenge-Driven GenAI4EU Booster (RIA) with Deadline date 2 October 2025.
In view of this, and in order to avoid any negative outcome for applicants, the Commission has decided to cancel the corresponding procedure in accordance with the General Annexes of the HE Work Programme 2025.
However, the Commission remains fully committed to supporting this domain, and will propose to the Programme Committee for Cluster 4 – Digital, Industry and Space, composed of Member State/Associated Countries representatives, to republish such topic at the earliest opportunity, addressing the legal uncertainty while minimising changes in the technical content of the call text. Every effort will be made to limit the delay of the intended support to these objectives, and information sessions will be organised to clarify the content of the call text and support the community preparing proposals.
Please note that due to a technical issue, during the first days of publication of this call, the topic page did not display the description of the corresponding destination. This problem is now solved.
In addition to the information published in the topic page, you can always find a full description of the Destination 4 ("Achieving open strategic autonomy in digital and emerging enabling technologies") that are relevant for the call in the Work Programme 2025 part for "Digital, Industry and Space". Please select from the work programme the destination relevant to your topic and take into account the description and expected impacts of that destination for the preparation of your proposal.